Experimental Study on Pulmonary Function and Lung Growth after Living-Donor Lobar Lung Transplantation

活体肺叶移植后肺功能及肺生长的实验研究

• 批准号: 14571266
• 负责人: DATE Hiroshi
• 金额: $ 2.18万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571266/
• 关键词: Living-Donor Lobar Lung Transplantation; Donor; Recipient; Pulmonary artery pressure; Arterial oxygen tension; 動脈血酸素分圧

Objective: Bilateral living-donor lobar lung transplantation has become an accepted alternative to cadaveric lung transplantation. Because only one lobe is implanted in each chest cavity, this procedure seems to be best suited for children and small adults. The purpose of this study was to develop a technique of unilateral double lobar lung transplantation which might be applied to large adult patients.Methods: Unilateral double lobar lung transplantation was performed in six weight-matched pairs of dogs. In donor animals, the right middle, lower and cardiac lobes were separated as a right graft and the left lower lobe was separated as a left graft. In recipient animals, these two grafts were implanted in the right hemithorax after right pneumonectomy. The left graft was implanted as a right upper lobe, having been rotated 180 degrees along the vertical axis and then 180 degrees along the horizontal axis. The right graft was implanted in the natural anatomic position. Function of the transplanted grafts was assessed for 3 hours after ligation of the left main pulmonary artery while animals were ventilated with 100% oxygen.Results: Morphological adaptation of the two grafts in the right hemithorax was found to be excellent. All 6 animals survived the assessment period with excellent pulmonary function. At the end of the 3-hour assessment period, the arterial oxygen tension was 519 ± 31 mmHg and the mean pulmonary artery pressure was 30.5 ± 1.7 mmHg.Conclusions: Unilateral double lobar lung transplantation was technically possible and associated with satisfactory early pulmonary function in a canine experimental model.

目的：双边活体肺叶移植已成为尸体肺移植的公认替代方案。由于每个胸腔中仅植入一个肺叶，因此该手术似乎最适合儿童和小成人。本研究的目的是开发一种可应用于体型较大的成年患者的单侧双叶肺移植技术。方法：对六对体重匹配的狗进行单侧双叶肺移植。在供体动物中，将右中叶、下叶和心叶分离为右移植物，将左下叶分离为左移植物。在受体动物中，在右肺切除术后将这两个移植物植入右半胸。左侧移植物作为右上叶植入，已沿垂直轴旋转 180 度，然后沿水平轴旋转 180 度。右侧移植物被植入到自然解剖位置。结扎左主肺动脉后，在动物用 100% 氧气通气的情况下，对移植的移植物的功能进行 3 小时的评估。结果：发现右半胸的两个移植物的形态适应非常好。所有 6 只动物均在评估期存活，肺功能良好。 3 小时评估期结束时，动脉氧分压为 519 ± 31 mmHg，平均肺动脉压为 30.5 ± 1.7 mmHg。结论：单侧双叶肺移植在技术上是可行的，并且与犬实验模型中令人满意的早期肺功能相关。

项目成果

The technique of unilateral double lobar lung transplantation in a canine model.

犬模型单侧双叶肺移植技术。

• 发表时间: 2004
• 期刊: Journal of Thoracic and Cardiovascular Surgery 127
• 作者: Okutani D;et al.
• 通讯作者: et al.

The technique of unilateral double lobar lung transplantation in a canine model

犬单侧双叶肺移植技术

• 发表时间: 2004
• 期刊: J Thorac Cardiovasc Surg 127
• 作者: Okutani D;Date H;Hayama M;Inokawa H;Okazaki M;Nagahiro I;Sano Y;Aoe M;Shimizu N
• 通讯作者: Shimizu N