Experimental study to repair non-heart beating donor lung using ex-vivo lung perfusion for clinical application

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One of the main obstacles in performing cadaveric lung transplantation from brain dead donor is shortage of available donor, especially in Japan. The purpose of this experimental animal study was to establish a clinically applicable method for lung transplantation utilizing non-heart-beating donors. The donor lungs obtained after cardiac arrest without heparinization were repaired by ex-vivo lung perfusion (EVLP) and were implanted to the recipient animal. Three experimental studies were conducted during 2011-13. 1) EVLP provided better lung preservation than cold static preservation using a canine left lung transplantation model in 2011. 2) Hypothermic EVLP repaired warm ischemic lung injury in a rat perfusion model in 2012. 3) Short term hypothermic EVLP repaired warm ischemic lung injury in a canine left lung transplantation model in 2013.