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Study of the factors that affect postoperative recovery

影响术后康复因素的研究

基本信息

批准号：
14571432
负责人：
SHIRAKAMI Gotaro
金额：
$ 2.24万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571432/
关键词：
Ambulatory surgery Postoperative recovery Postoperative nausea and vomiting Heart rate variability Anesthesia autoregulation Airway ciliary motility Inhalation anesthetics Intravenous anesthetics 麻酔補助薬帰宅基準 Bispectral Index

项目摘要

1)There was a significant positive correlation between the duration of anesthesia and time to meet the discharge criteria in ambulatory anesthesia patients.2)Preanesthesia hydration shortened the time to meet the discharge criteria in patients undergoing ambulatory surgical patients anesthetized with inhaled sevoflurane.3)Sevoflurane anesthesia with supplemental fentanyl increased the incidence of postoperative nausea and vomiting and delayed the postoperative recovery in patients undergoing ambulatory breast cancer surgery, in comparison with sevofururane anesthesia without fentanyl.4)Volatile induction and maintenance of anesthesia (VIMA) with sevoflurane and nitrous oxide increased the incidence of postoperative nausea in patients undergoing day-case hysteroscopy, in comparison with VIMA with sevoflurane only.5) The high frequency band (HF) of heart rate variability (HRV) was high and the ratio of low frequency band (LF)/HF was low in postanesthesia patients undergoing ambulatory breast cancer surgery under propofol anesthesia, in comparison with sevoflurane anesthesia.6)HF of HRV increased after induction of spinal anesthesia and returned to preanesthesia level with the recovery of pain and motor sensations.7)The automated closed-loop control system for propofol infusion using a model predictive controller, which uses bispectral index (BIS) value as a controlled variable, decreased the drug consumption and maintain the BIS value more precisely around the target set point, in comparison with manual control by anesthesiologists.8)Isoflurane and halothane depressed cilirary motility strongly, but seveflurane preserved it in cultured rat tracheal epithelial cells. Pentbarbilal inhibited it potently and high dose of ketamine augmented it. Midazolam and dexmedetomidine did not affect it.

1）日间麻醉患者麻醉持续时间与满足出院标准的时间呈显着正相关。2）麻醉前补水缩短了吸入七氟烷麻醉的日间手术患者满足出院标准的时间。3）七氟醚麻醉补充芬太尼增加术后恶心发生率与不使用芬太尼的七呋喃麻醉相比，接受门诊乳腺癌手术的患者出现呕吐并延迟术后恢复。4) 与七氟醚的 VIMA 相比，七氟烷和一氧化二氮的挥发性诱导和维持麻醉 (VIMA) 增加了接受日间宫腔镜检查的患者术后恶心的发生率 5）与七氟醚麻醉相比，异丙酚麻醉下进行门诊乳腺癌手术的患者麻醉后心率变异性（HRV）高频段（HF）较高，低频段（LF）/HF比值较低。6）椎管内麻醉诱导后心率变异性（HRV）HF升高，随着疼痛和运动恢复恢复至麻醉前水平 7) 使用模型预测控制器的异丙酚输注自动闭环控制系统，使用脑电双频指数 (BIS) 值作为控制变量，与麻醉师的手动控制相比，减少了药物消耗，并将 BIS 值更精确地维持在目标设定点附近。 8) 异氟烷和氟烷强烈抑制纤毛运动，但七氟烷将其保留在培养大鼠气管上皮细胞。 Pentbarbilal 可有效抑制它，而高剂量的氯胺酮可增强它。咪达唑仑和右美托咪定对其没有影响。