Study of the factors that affect the quality of life in postoperative patients

1)门诊手术后恢复时间延长主要是由于术后不适症状（疼痛、术后恶心和呕吐（PONV）、嗜睡/头晕/疲劳），其次是由于社会/系统问题。延迟的患者更频繁地抱怨术后疼痛，并报告较低的自评恢复正常活动（RNA）水平和门诊手术的可接受性。满意度低的患者更频繁地报告术后不愉快症状，RNA水平和可接受性较低。20%的患者在门诊手术后有中度至重度疼痛。在短期乳腺癌手术中，七氟醚麻醉联合芬太尼显示了较高的PONV率和术后恢复延迟;全静脉麻醉（TIVA）显示了较七氟醚麻醉更低的术中血流动力学变化和心率变异性（HRV）抑制，较低的PONV率和更快的术后恢复;七氟醚麻醉 ...更多信息 联合使用右美托咪定可增加术中低血压和心动过缓的发生率，并延迟苏醒，但不影响术后疼痛和PONV的严重程度;七氟醚“轻度”麻醉可加快苏醒，但不影响PONV频率和HRV抑制。2）建立了以脑电双频指数（BIS）为控制变量的丙泊酚输注自动闭环控制系统。在TIVA中，它比手动控制更精确地保持BIS值。3）在体外培养的大鼠气管上皮细胞中，硫喷妥钠、咪达唑仑和右美托咪定对纤毛运动无影响，而大剂量氯胺酮和芬太尼对纤毛运动有促进作用，戊巴比妥对纤毛运动有强烈抑制作用。氟烷和异氟烷使其显著降低，但三氟醚的作用最小。异氟烷抑制异丙肾上腺素诱导的纤毛刺激，但不抑制细胞内cAMP水平的增加。异氟烷不影响细胞内ATP水平。少

1)Prolonged recovery after ambulatory surgery is mainly due to postoperative unpleasant symptoms (pain, postoperative nausea and vomiting (PONV), drowsiness/dizziness/fatigue) and secondly due to social/system problems. Delayed patients complained postoperative pain more frequently, and reported lower self-rated resumption of normal activity (RNA) levels and acceptability for ambulatory surgery. Patients in lower satisfaction levels reported postoperative unpleasant symptoms more frequently, and lower RNA level and acceptability. Twenty percent of patients had moderate to severe pain after ambulatory surgery. In short-stay breast cancer surgery, sevoflurane anesthesia combined with fentanyl revealed higher PONV rate and delayed postoperative recovery ; total intravenous anesthesia (TIVA) revealed lower intraoperative hemodynamic changes and inhibition in heart rate variability (HRV), lower PONV rate, and faster postoperative recovery than sevoflurane anesthesia; sevoflurane anesthesia … More combined with dexmedetomidine revealed intraoperative hypotension and bradycardia episodes more frequently, and delayed recovery without affecting severity in postoperative pain and PONV ; sevoflurane "light" anesthesia revealed faster emergence without affecting PONV frequency and HRV inhibition.2)The automated closed-loop control system for propofol infusion using bispectral index (BIS) value as a controlled variable was developed. In TIVA, it maintained the BIS value more precisely than manual control. However, in monitored anesthesia care, control was difficult.3)In cultured rat tracheal epithelial cells, thiopental, midazolam and dexmedetomidine did not affect ciliary motility, but high doses of ketamine and fentanyl augmented it and pentbarbital depressed it strongly. Halothane and isoflurane decreased it vigorously, but seveflurane did minimally. Isoflurane inhibited isoproterenol-induced cilio-stimulation, but did not depress increased intracellular cAMP levels. Isoflurane did not affect intracellular ATP levels. Less