Experimental study for the effect of artificial ventilation and environment on the cardiac autonomic nervous system activity in the central nervous system ischemia

人工通气及环境对中枢神经系统缺血时心脏自主神经活动影响的实验研究

• 批准号: 14571443
• 负责人: KAWAMOTO Masashi
• 金额: $ 1.98万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571443/
• 关键词: Heart Rate Variability Analysis; Arterial Pressure Variability Analysis; Central Nervous System; Brain Death; Artificial Ventilation

Artificial ventilation with positive end-expiratory pressure (PEEP) is commonly applied for brain damaged patients. However, the effect of the ventilation on brain function including cardiovascular autonomic nervous system (CANS) activity is not well elucidated. In a first study, we investigate the effect of 5 cmH2O PEEP on CANS activity in the brain damaged rabbits under general anesthesia. We found that 5 cmH2O PEEP depressed CANS activity during the progression of brain damage in rabbits and it was partly due to aggravated brain function induced by PEEP. In a second study, we measured heart rate (HR) variability and systolic arterial pressure (SAP) variability, and analyzed impulse response analysis results between HR and SAP in brain damaged rabbits in order to determine spinal cord function under a brain damaged condition. We found that HR variability was mainly controlled by the brain and SAP variability was mediated by the brain through the spinal cord, while SAP variability was related to HR variability through the spinal cord in brain damaged rabbits. We then concluded that CANS activity was depressed in the animals with acute brain damage during mechanical ventilation using 5 cmH_2O PEEP, and that HR variability is mainly controlled by the brain and SAP variability is mediated by the brain through the spinal cord. 10. KEY WORDS

脑损伤患者常采用呼气末正压(PEEP)人工呼吸机。然而，呼吸机对包括心血管自主神经系统(CANS)活动在内的脑功能的影响尚未得到很好的阐明。在第一项研究中，我们观察了5 cmH2O呼气末正压对全麻下脑损伤兔CANS活性的影响。我们发现，在兔脑损伤过程中，5 cmH2O对CaNS活性有抑制作用，部分原因是PEEP引起的脑功能加重。在第二项研究中，我们测量了脑损伤兔的心率(HR)变异性和动脉收缩压(SAP)变异性，并分析了HR和SAP之间的脉冲响应分析结果，以确定脑损伤条件下的脊髓功能。我们发现，在脑损伤兔中，HR变异性主要由脑控制，SAP变异性由脑通过脊髓介导，而SAP变异性与通过脊髓的HR变异性有关。我们得出结论：急性脑损伤动物使用5 cmH_2O PEEP时，CANS活性受到抑制，HR变异性主要由脑控制，SAP变异性由脑通过脊髓介导。10.关键词

项目成果

Shigeaki Kurita, et al.: "Positive end-expiratory pressure depressed cardiovascular autonomic nervous system activity in acute brain damaged rabbits under general anesthesia"Hiroshima Journal of Medical Science. 52(4). 59-67 (2003)

Shigeaki Kurita 等人：“全身麻醉下急性脑损伤兔子的呼气末正压抑制心血管自主神经系统活动”《广岛医学科学杂志》。

Masashi Kawamoto, et al.: "Control of Arterial Pressure Variability Through Spinal Cord in Brain Damaged Rabbit"Anesthesia and Resuscitation. 39. 57-64 (2003)

Masashi Kawamoto 等人：“通过脑损伤兔子脊髓控制动脉压变异”麻醉和复苏。

Masashi Kawamoto, et al.: "Control of Arterial Pressure Variability Through Spinal Cord in Brain Damaged Rabbit"Anesthesia and Resuscitation. 39(2). 57-64 (2003)

Masashi Kawamoto 等人：“通过脑损伤兔子脊髓控制动脉压变异”麻醉和复苏。

Masashi Kawamoto, et al.: "Control of Arterial Pressure Variability Through Spinal Cord in Brain Damaged Rabbit"Anesthesia and Resuscitation. 39・2. 57-64 (2003)

Masashi Kawamoto 等人：“通过脑损伤兔子的脊髓控制动脉压变化”麻醉与复苏 57-64 (2003)。

Shigeaki Kurita, et al.: "Positive end-expiratory pressure depressed cardiovascular autonomic nervous system activity in acute brain damaged rabbits under general anesthesia"Hiroshima Journal of Medical Science. 52. 59-67 (2003)

Shigeaki Kurita 等人：“全身麻醉下急性脑损伤兔子的呼气末正压抑制心血管自主神经系统活动”《广岛医学科学杂志》。