Control of arterial pressure variability by heart rate variability through spinal cord in brain damage

通过脊髓心率变异性控制脑损伤中的动脉压变异性

• 批准号: 10671417
• 负责人: KAWAMOTO Masashi
• 金额: $ 1.34万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671417/
• 关键词: heart rate variability; arterial pressure variability; impulse response; spinal injury; brain damage; power spectral analysis; 心拍変動; 周波数解析; 周波数応答; インパルスレスポンス; 脊髄損傷; 脳幹損傷; 動脈圧変化

Power spectral analysis of heart rate (HR) variability (HRV) can estimate the cardiac autonomic nervous system function. We investigated the function of brain and spinal cord in their acute injury by the analysis of HRV and arterial pressure (AP) variability (APV), and impulse response (IR) between HR and AP.16 subjects were randomly assigned into 2 groups to receive spinal cord transection at C3-4 and brain damage by inflating an intracranial balloon. In BS group, the on-line data were digitally recorded before the brain damage and thereafter. The spinal cord was transected and the data were recorded. In SB group, the spinal cord was transected firstly and the brain damage was made secondly with same recording intervals as BS group. HRV and APV were analyzed.Spectral power was integrated at low and high frequency band areas. IR of HR to AP and AP to HR were analyzed by Fourier and inverse-Fourier transformations using the data in time domain. Statistical analysis was made within a group and between the groups. p<0.05 was determined significant.Spinal transection depressed HR in SB group and BS group, and maintained sympathovagal balance high in APV, while brain damage depressed the balance in HRV. In maximal IR of HR to AP, brain damage had significant effect than spinal damage, while no effect was seen in IR of AP to HR. HRV is controlled by the brain and APV is mediated by the brain through the spinal cord. APV is controlled by HRV through spinal cord in brain damage.In conclusion, we revealed the nature of autonomic nervous activity in animals receiving spinal cord and brain damage. It was suggested that spinal cord is not only a conduction system of brain impulses but the organ showing peripheral conduction of autonomic impulses.

心率变异性（HRV）的功率谱分析可以评价心脏自主神经系统的功能。通过分析心率变异性（HRV）、动脉压（AP）变异性（APV）和心率与AP之间的脉冲反应（IR），探讨急性损伤时脑和脊髓的功能。16例受试者随机分为2组，分别接受C3-4脊髓横断和颅内球囊损伤。BS组在脑损伤前和脑损伤后均进行数字化记录。横断脊髓并记录数据。SB组先切断脊髓，再造成脑损伤，记录时间与BS组相同。分析HRV和APV，并在低频和高频区域进行频谱功率积分。利用时域数据，通过傅立叶变换和逆傅立叶变换分析HR到AP和AP到HR的IR。组内和组间进行统计学分析。脊髓横断使SB组和BS组HR降低，APV维持较高的交感迷走神经平衡，而脑损伤使HRV的平衡降低。在HR对AP的最大IR中，脑损伤的影响明显大于脊髓损伤，而AP对HR的最大IR无影响。HRV由脑控制，APV由脑通过脊髓介导。脑损伤时，APV通过脊髓受HRV控制。总之，我们揭示了动物接受脊髓和脑损伤后自主神经活动的本质。提示脊髓不仅是脑神经冲动的传导系统，而且是植物神经冲动的外周传导器官。

项目成果

Masashi Kawamot, et al.: "Effects of one lung ventilation on cardiac autonomic nervous system in rabbits"Anesthesia and Resuscitation. 36(2). 87-91 (2000)

Masashi Kawamot 等人：“单肺通气对兔子心脏自主神经系统的影响”麻醉和复苏。

Masashi Kawamoto, Kotaro Kaneko, Osafumi Yuge: "Effects of one lung ventilation on cardiac autonomic nervous system in rabbits"Anesthesia and Resuscitation. 36(2). 87-91 (2000)

Masashi Kawamoto、Kotaro Kaneko、Osafumi Yuge：“单肺通气对兔子心脏自主神经系统的影响”麻醉和复苏。

Masashi Kawamoto, Shigeaki Kurita, Syozo Hidaka, Osafumi Yuge: "Control of Arterial Pressure by Heart Rate Through Spinal Cord in Brain Damaged Rabbit"under submission.

Masashi Kawamoto、Shigeaki Kurita、Syozo Hidaka、Osafumi Yuge：“通过脑损伤兔子的脊髓通过心率控制动脉压”正在提交。