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Continuous analysis of urine contents in intensive care unit

重症监护病房尿液含量的连续分析

基本信息

批准号：
14571458
负责人：
TANAKA Yoshifumi
金额：
$ 1.73万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

Compared with the attention to the concentration of electrolytes in blood, that of them in urine was minimized because of large variety in normal range. Urinary output and concentrations of electrolytes or other substances are strongly affected by the circulatory conditions or hormonal conditions. We devised an automatic and continuous measuring system of urinary output and concentration of each solute (Sodium, Potassium, Urea, Creatinine) and investigated of them in intensive care unit. The results of the investigation was quite interesting one. First of all, the relationship of the urinary volume and osmolarity of it was in inverse proportion. As the concentration of urea or creatinine increases, the osmolarity of urine was increased. However the relationship of sodium and potassium concentrations versus osmolarity was different and complicated. In the isosmotic urinary situation, the sodium and potassium concentrations depicted precisely 110 mEq/L and 10 mEq/L respectively. Then as the osmolarity in urine increases the concentration of sodium was decreased the minimized to 60 mEq/L at 560 mosmol, then the concentration of it was increased proportionally. The potassium concentration in urine was increased proportionally until to the 560 mosmol in urine osmolarity and measured almost 100 mEq/L of the concentration, after then the value was decreased. Those results seems to be quite natural phenomenon. We obtain 2 ml/kg/hour of fluid and 1 ml/kg/hour of urination in normal situation. Hence, two times of isosmotic condition of urinary output might be best suitable situation for sodium reabsorption and potassium secretion. These results also explains why hypokalemia will occur in natriuretic condition.

与关注血液中的电解质浓度相比，尿液中的电解质浓度由于在正常范围内变化较大而被最小化。尿量和电解质或其他物质的浓度受循环状况或荷尔蒙状况的强烈影响。我们设计了一套自动、连续的尿量和各种溶质(钠、钾、尿素、肌酐)浓度的测量系统，并在重症监护病房对其进行了研究。调查的结果相当有趣。首先，尿量与尿液渗透压成反比。随着尿素或肌酐浓度的增加，尿液渗透压升高。然而，钠、钾浓度与渗透压的关系是不同的，也是复杂的。在等渗尿状态下，钠和钾浓度分别精确地描绘为110mEq/L和10mEq/L。随着尿液渗透压的升高，钠浓度逐渐降低，在560momoL时降至60mEq/L，而后按比例升高。尿钾浓度按比例升高至尿渗透压的560mEq/L，之后呈下降趋势。这些结果似乎是相当自然的现象。在正常情况下，我们获得2ml/kg/小时的液体和1ml/kg/小时的尿量。因此，两倍等渗的尿量条件可能是钠重吸收和钾分泌的最佳条件。这些结果也解释了为什么在利钠状态下会出现低钾血症。