Clnical and pathological investigation of pelvic endometriosis

盆腔子宫内膜异位症的临床及病理研究

• 批准号: 14571571
• 负责人: ISHIMARU Tadayuki
• 金额: $ 1.66万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571571/
• 关键词: Endometriosis; Cytokine; growth factor; macrophage; HGF; Endometriosis; Cytokine; Macrophage; c-Met; Morphological; Dioxin

We investigated the following relevant particulars to elucidate the relationship between morphological appearance and growth of pelvic endometriosis, (1)relationship between peritoneal fluid (PF) concentrations of interleukin-6, ovarian steroids and hepatocyte growth factor (HGF) in different revised-ASRM staging and morphologic appearances of endometriosis, (2)the variations of activity in the different colored morphologic lesions as proposed by the ASRM classification in women with endometriosis, (3)relationship between the activity of the eutopic endometrium and activity of the ectopic endometrium, (4)the possible involvement of HGF in the cellular changes of pelvic mesothelium and their association with macrophage (Mφ) infiltration depending on the activity of pelvic endometriosis, (5)the distribution of Mφ infiltration in eutopic and ectopic endometrium throughout the menstrual cycle. We obtained the following conclusions, respectively, (1)early staging and red color appearance of endometriosis are associated with the elevation in PF concentrations of HGF, IL-6 and estradiol, (2)both PF and intact tissue in opaque red lesions display higher activity than that in non-opaque red lesions, or black lesions, (3)immunoexpression of HGF and c-Met in the eutopic endometrium of patients with pelvic endometriosis is possibly useful to predict, greatei activity of the ectopic endometrium, (4)adjacent peritoneum of pelvic endometriotic lesions manifest an inflammatory response and HGF might be involved in the cellular change of peritoneal mesothelium in women with pelvic endometriosis, (5)the peritoneal lesions of early and active endometriosis and their adjacent peritoneum harbor abundant Mφ which could be involved in the growth of endometriosis.

我们研究了以下有关细节，以阐明盆腔子宫内膜异位症的形态学表现与生长的关系：（1）腹膜液（PF）中白细胞介素-6（IL-6）、卵巢类固醇和肝细胞生长因子（HGF）的浓度与子宫内膜异位症不同的修订ASRM分期和形态学表现的关系;（2）子宫内膜异位症患者ASRM分类中不同颜色形态病变的活性变化;（3）在位内膜活性与异位内膜活性之间的关系;（4）HGF可能参与了盆腔间皮细胞的变化，并与巨噬细胞（Mφ）浸润有关，这取决于盆腔子宫内膜异位症的活动性。（5）Mφ浸润在整个月经周期在位和异位内膜中的分布。我们分别得出以下结论：（1）子宫内膜异位症的早期分期和红色外观与PF中HGF、IL-6和雌二醇的浓度升高有关;（2）不透明红色病变中PF和完整组织的活性均高于非不透明红色病变或黑色病变，（3）HGF和c-Met在盆腔子宫内膜异位症患者在位内膜中的表达可能有助于预测异位内膜的高度活动性，（4）盆腔子宫内膜异位症患者邻近腹膜存在炎症反应，HGF可能参与了盆腔子宫内膜异位症患者腹膜间皮细胞的变化，（5）早期和活动期子宫内膜异位症患者的腹膜病变及其邻近腹膜内含有丰富的Mφ，Mφ可能参与了子宫内膜异位症的生长。

项目成果

石丸 忠之: "子宮内膜症の病理形態と発育増殖"日本産科婦人科学会雑誌. 54. 1158-1163 (2002)

Tadayuki Ishimaru：“子宫内膜异位症的病理形态和生长增殖”日本妇产科学会杂志54。1158-1163（2002）。

Tadayuki Ishimaru: "Morphological appearance and growth of pelvic endometriosis"Acta Obstetrica et Gynecologica Japonica. 54(8). 1158-1163 (2002)

Tadayuki Ishimaru：“盆腔子宫内膜异位症的形态学表现和生长”Acta Obstetrica et Gynecologica Japonica。

Khaleque Newaz Khan: "Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum"Fertil Steril. 81(3)(in press). (2004)

Khaleque Newaz Khan：“早期和晚期子宫内膜异位症和邻近腹膜的差异巨噬细胞浸润”Fertil Steril。

カレク・ネワズ・カーン: "Immunoexpression of HGF and c-Met receptor in eutopic endometrium predicts the activity of ectopic endometrium"Fertilty and Sterility. 79. 173-181 (2003)

Khalek Newaz Khan：“在位子宫内膜中 HGF 和 c-Met 受体的免疫表达可预测异位子宫内膜的活性”生育力和不育。

Khaleque Newaz Khan: "Immunoexpression of HGF and c-Met receptor in eutopic endometrium predicts, the activity of ectopic endometrium"Fertility and Sterility. 79(1). 173-181 (2003)

Khaleque Newaz Khan：“在位子宫内膜中 HGF 和 c-Met 受体的免疫表达预测异位子宫内膜的活性”生育和不育。