THE INDUCTION OF HIBERNATION OF FETAL CARDIOCYTE BY ADENOSINE

腺苷诱导胎儿心肌细胞冬眠

• 批准号: 14571588
• 负责人: SAWA Rintaro
• 金额: $ 1.92万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571588/
• 关键词: ADENOSINE; FEATL CARDIOCYTE; HIBERNATION; 5'-NUCLEOTIDASE; ADENOSINE DEAMINASE; ハイバーネーション; 5'-nucleotiduse

During the decrease of coronary blood flow, the compensative mechanism acts to maintain coronary flow by lowering cardiac function in the adults. This mechanism has been known as hibernation. Recently, the relationship between adenosine and hibernation has been well investigated. The bioactivity of adenosine in fetal brain and cardiocyte are much higher than those in adults, which may contribute to the low rate of cardiac diseases in fetus and newborn. We evaluated changes in 5'-nucleotidase and adenosine deaminase levels during fetal ischemic and reperfusion stress in chronically instrumented fetal goats, and demonstrated that fetuses have a compensative mechanism that tends to increase adenosine levels. However, excessive adenosine has cytotoxic effects, so fetuses have also have a self-defense mechanism that dampens excessive adenosine. These compensative mechanisms may induce fetal hibernation to adapt limited oxygen supply in utero, which eventually contribute to adapt the stressful conditions in utero, such as pregnancy-induced hypertension, IUGR, infection and twin pregnancy.

在冠状动脉血流量减少的过程中，代偿机制通过降低成人的心功能来维持冠脉流量。这种机制被称为冬眠。近年来，腺苷与冬眠的关系得到了很好的研究。胎儿脑和心肌中腺苷的生物活性远高于成人，这可能是胎儿和新生儿心脏病发病率较低的原因之一。我们评估了5‘-核苷酸酶和腺苷脱氨酶水平在胎儿缺血和再灌流应激过程中的变化，证明了胎儿有一种倾向于增加腺苷水平的代偿机制。然而，过量的腺苷具有细胞毒性作用，因此胎儿也有一种自我防御机制，可以抑制过量的腺苷。这些代偿机制可能诱导胎儿冬眠以适应宫内有限的氧气供应，最终有助于适应宫内应激条件，如妊娠高血压综合征、IUGR、感染和双胎妊娠。

项目成果

Yamada Y: "Effect of maternal oxygen supplementation on fetal oxygenation and lipid peroxidation following a single umbilical cord occlusion in fetal goats."J Nippon Med Sch. 70. 165-171 (2003)

Yamada Y：“母羊补充氧气对胎山羊单次脐带闭塞后胎儿氧合和脂质过氧化的影响。”J Nippon Med Sch。

Miura A: "Fetal plasma prostaglandin F2 alpha and cortisol responses to high-dose endotoxin administration in fetal goats."J Nippon Med Sch. 70. 151-156 (2003)

Miura A：“胎儿血浆前列腺素 F2 α 和皮质醇对胎山羊高剂量内毒素的反应。”J Nippon Med Sch。

Yoneyama, et al.: "Plasma 5'-nucleotidase Activities and UricAcid Levels in Women with Preeclampsia"Gynecol Obstet Invest. 54. 168-171 (2002)

Yoneyama 等人：“先兆子痫女性的血浆 5-核苷酸酶活性和尿酸水平”Gynecol Obstet Invest。

Yoneyama, et al.: "Serum Adenosine Deaminase Activity in Women with Preeclampsia"Gynecol Obstet Invest. 54. 164-167 (2002)

Yoneyama 等人：“先兆子痫女性的血清腺苷脱氨酶活性”Gynecol Obstet Invest。

Yoneyama Y: "Changes in the proporsion of T helper-1 and T helper-2 cells in cord blood after premature of membranes."Arch Gynecol Obstet. 267(4). 217-220 (2003)

Yoneyama Y：“胎膜早熟后脐带血中 T 辅助细胞 1 和 T 辅助细胞 2 细胞比例的变化。”Arch Gynecol Obstet。