Mechanism of neuronal protection by adenosine in the fetus.

腺苷对胎儿神经元的保护机制。

• 批准号: 08671937
• 负责人: SAWA Rintaro
• 金额: $ 0.96万
• 依托单位: NIPPON MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671937/
• 关键词: HUMAN FETUS; IUGR; ADENOSINE; HYPOXANTHINE; CORDOCENTESIS; 脳児; 脳障害; プリン代謝; 胎児循環; 臍帯穿刺; ハイポキサンチン

OBJECTIVE : Our purpose in this study was to investigate the relationship between fetal plasma purine metabolites and lactate concentrations, blood gases, and pH in small-for- gestational-age fetuses.STUDY DESIGN : Cordocentesis was performed in 34 growth-retarded fetuses at 31-35 week's gestation for measuremwnt of umbilical venous plasma concentrations of adenosine, hypoxanthine, blood gases, pH and lactate concentrations.RESULTS : Umbilical venous plasma adenosine concentration was inversely related to umbilical venous P02 and pH, while umbilical venous plasma concentrations of hypoxanthine was found to be increased significantly, in parallel with the degree of acidosis (r=-O.74, p<O.05) and base deficit (r=-O.41, p<O.05), but not to be bear a significant relationship to the degree of hypoxemia or other measured variables.CONCLUSION : We posturate that the acompanying elevation of plasma adenosine elicits protective adaptation during fetal asphyxia as a stress response while increases in the plasma concentration of hypoxanthine may reflect an impaired physiological state in growth -retarded fetuses before labor.

目的：探讨小于胎龄胎儿血浆嘌呤代谢产物与乳酸浓度、血气、pH的关系。研究设计：对34例孕31~35周的生长迟缓胎儿进行脐带穿刺术，测定脐静脉血中腺苷、次黄嘌呤、血气、pH和乳酸浓度。结果：脐静脉血中腺苷浓度与脐静脉血P02、pH呈负相关，次黄嘌呤浓度与酸中毒程度呈显著正相关(r=0.74，p&lt；但与低氧血症程度或其他可测变量无明显关系。结论：血浆腺苷升高可作为一种应激反应，在胎儿窒息时引起保护性适应，而血浆次黄嘌呤浓度的升高可能反映了胎儿产前生理状态的受损。

项目成果

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Suzuki S.et al: "Maternal plasma adenosine levels in pregnancies" (Trophoblast research). 11 (in press). (1999)

Suzuki S.et al：“妊娠期母体血浆腺苷水平”（滋养层研究）。

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铃木 S.：“医源性单羊膜双胎妊娠伴进行性双胎输血综合征”胎儿诊断疗法。