THE MECHANISM OF ISCHEMIC TOLERANCE INDUCTION BY ADENOSINE IN FETAL CARDIAC MUSCLE

腺苷诱导胎儿心肌缺血耐受的机制

• 批准号: 11671656
• 负责人: SAWA Rintaro
• 金额: $ 2.05万
• 依托单位: NIPPON MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671656/
• 关键词: adenosine; ischemic preconditioining; 5'-nucleotidase; 心筋; 5'-nucleotidase; 胎児; 5′-ヌルオチダーゼ; 胎児心筋; 5'-ヌクレオチダーゼ; ヒツジ慢性実験モデル; 臍帯圧迫

[PURPOSE] The purpose of this study is to evaluate the effect of adenosine on the induction of ischemic tolerance in fetal cardiac muscle.[METHOD] We measured cardiac adenosine and 5'-nucleotidase during ischemia with and without ischemic preconditioining in fetal sheep.[RESULTS] The significant elevation of cardiac adenosine after ischemic preconditioining was associated with an increase of 5'-nucleotidase activity.[CONCLUSION] This support the powerful effect.of adenosine on the induction of ischemic tolerance in fetal cardiac muscle.

[目的]探讨腺苷在胎羊心肌缺血耐受诱导中的作用。[方法]测定缺血预适应前后胎羊心肌组织中腺苷和5‘-核苷酸酶的变化。[结果]心肌缺血预适应后心肌腺苷水平显著升高，与5’-核苷酸酶活性升高有关。[结论]腺苷具有诱导胎羊心肌缺血耐受的作用。

项目成果

Suzuki S et al: "Changes in letal plasma adenosine and xanthine sencentrations during letal asphyxia with maternal oxygen administration in erves"Tohoku J Exp Med. 192. 275-281 (2000)

Suzuki S 等人：“在致死窒息期间母体给氧时致死血浆腺苷和黄嘌呤浓度的变化”Tohoku J Exp Med。

Yoneyama Y, et al.: "Plasma adenosine levels increase in normal pregnant women."Am J Obstet Gynecol. 182. 1200-3 (2000)

Yoneyama Y 等人：“正常孕妇的血浆腺苷水平增加。”Am J Obstet Gynecol。

澤 倫太郎 他: "アデノシンによる胎仔心筋の虚血耐性機構の解明"日産婦誌. 52. 301(S-225) (2000)

Rintaro Sawa 等：“腺苷诱导的胎儿心肌缺血耐受机制的阐明”Nissan Gynecology. 52. 301(S-225) (2000)。

Takeuchi T et al: "Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia"Gynecol Obstet Invest. 51. 36-39 (2001)

Takeuchi T 等人：“先兆子痫中血浆腺苷对体外血小板聚集的调节”Gynecol Obstet Invest。

Yoneyama Y, et al.: "Changes in plasma adenosine levels during normal pregnancy."Gynecol Obstet Invest. 50. 145-8 (2000)

Yoneyama Y 等人：“正常妊娠期间血浆腺苷水平的变化。”Gynecol Obstet Invest。