Effect of several drugs on disruption of blood-aqueous barrier

几种药物对血水屏障破坏的影响

• 批准号: 14571661
• 负责人: HAYASAKA Seiji
• 金额: $ 1.86万
• 依托单位: University of Toyama (2005)Toyama Medical and Pharmaceutical University (2002-2004)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571661/
• 关键词: blood-aqueous barrier; aqueous flare; aqueous proteir; uvitis; corticosteroid; NSAID; cyclooxygenase; betaxolol; S100A8; S100A9; N-アセチル-システイン; ロリプラム; COX-1; COX-2; レーザー虹彩切開術; 抗緑内障薬; 抗炎症薬; エピネフリン; 非ステロイド剤

Disruption of blood-aqueous barrier elevates protein and flare in the anterior chamber. PGE2,PGE2 receptor antagonist, and isopropyl unoprostone (PG-related antiglaucoma agent) disrupted the blood -aqueous barrier in pigmented rabbits. Betaxolol (antiglaucoma agent having calcium blocking activity), apraclonidine (α 2 agonist), epinephrine (β 2 antagonist), diviyefrin (β 2 antagonist), betamethasone (corticosteroid), fluorometholone (corticosteroid), diclofenac (non-steroidal anti-inflammatory drug), pranoprofen (non-steroidal anti-inflammatory drug), baicalein (a component isolated from medicinal herb), baicalin (a component isolated from medicinal herb), tramazoline (vasoconstructor), FR122047 (COX-1 inhibitor), and FR188582(COX-2 inhibitor) suppressed PGE2-induced aqueous, flare elevation in pigmented rabbits. Postoperative aqueous flare elevation was inhibited by Kakkon-to in cataract patients or by betaxolol in glaucoma patients. It is possible that these agents may be useful in treatment for uveitis.

血-房水屏障的破坏使前房中的蛋白质和闪光升高。PGE 2、PGE 2受体拮抗剂和异丙基乌诺前列酮（PG相关抗青光眼药物）破坏了有色兔的血-房水屏障。他洛尔（具有钙阻断活性的抗青光眼剂）、阿普拉尼定（α 2激动剂），肾上腺素（β 2拮抗剂），diviyefrin（β 2拮抗剂），倍他米松（皮质类固醇），氟米龙（皮质类固醇）、双氯芬酸（非甾体抗炎药），普拉洛芬（非甾体抗炎药），黄芩素黄芩苷（一种从草药中分离出来的成分）（从草药中分离的成分），曲马唑啉（血管构造剂）、FR 122047（考克斯-1抑制剂）和FR 188582（考克斯-2抑制剂）抑制了色素兔中PGE 2诱导的房水闪光升高。白内障患者的Kakkon-to或青光眼患者的倍他洛尔可抑制术后房水闪光升高。这些药物可能用于治疗葡萄膜炎。

项目成果

Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical corticosteroids and nonsteroidal anti-inflammatory drugs on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits"Ophthalmic Research. 35. 341-344 (2003)

Y.Hayasaka、S.Hayasaka、X.Y.Zhang、Y.Nagaki：“局部皮质类固醇和非甾体抗炎药对前列腺素 E2 诱导的色素兔房水耀斑升高的影响”眼科研究。

Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical antiglaucoma eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits"Investigative Ophthalmology and Visual Science. 43. 1142-1145 (2002)

Y.Hayasaka、S.Hayasaka、X.Y.Zhang、Y.Nagaki：“局部抗青光眼滴眼液对前列腺素 E2 诱导的色素兔子房水耀斑升高的影响”调查眼科和视觉科学。

Effect of topical botaxolol on acute elevation of aqueous flare after argon laser iridotomy

局部用肉他洛尔对氩激光虹膜切开术后房水急性升高的影响

• 发表时间: 2004
• 期刊: Annals of Ophthalmology 36
• 作者: Y.Hayasaka;S.Hayasaka;Y.Nagaki;X.Y.Zhang
• 通讯作者: X.Y.Zhang

Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical mydriatics and vasoconstrictors on prostaglandin E2-induoed aqueous flare elevation In pigmented rabbits"Ophthalmic Research. 35. 256-260 (2003)

Y.Hayasaka、S.Hayasaka、X.Y.Zhang、Y.Nagaki：“局部散瞳药和血管收缩药对有色兔子中前列腺素 E2 引起的房水耀斑升高的影响”眼科研究。

S.Yanagisawa, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, Y.Nagaki: "Effects of topical iganidipine on experimental elevation on aqueous flare induced by rostaglandin E2 and EP agonists in pigmented rabbits"Ophthalmic Research. 34. 195-199 (2002)

S.Yanagisawa、S.Hayasaka、X.Y.Zhang、Y.Hayasaka、Y.Nagaki：“局部伊加地平对有色兔中由罗他兰素 E2 和 EP 激动剂诱导的房水耀斑实验升高的影响”眼科研究。