Basic and clinical research of treatment for ocular disease by KANPO-drugs

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1. Basic researchWe investigated the effects of KANPO-druds for experimental uveitis. we report the results of new evidence acquired from the experiments.(1) The effects of KANPO-druds for experimental uveitis induced by topical prostaglandin E_2 KANPO-druds of ten-fold doses of human clinical dose were adiministered for 1 week before prostaglandin E_2 (10mug/ml) -treatment.The KANPO-druds of SAIREI-TO,KAKKON-TO and ORENGEDOKU-TO,respectively, did not inhibited the experimental uveitis.(2) The effects of KANPO-druds for experimental uveitis induced by lipopolysaccaharide(1) KAKKON-TO of five-fold doses of human clinical dose were administered for 1 week before lipopolysaccharide (0.5mug/kg) -treatment. But, the experimental uveitis were not inhibited.(2) SAIREI-TO were administered for 1 week before lipopolysaccharide (0.5mug/kg) -treatment. In ten-fold and three-fold doses of human clinical dose of SAIREI-TO,the experimental uveitis were significantly inhibited compared with control.