Basic and clinical studies of traditional Sino-Japanese(Kampo)medicines on ocular imflammation

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We investigate inhibitory effects of Kampo medicines on experimental aqueous flare elevation in pigmented rabbits, and on aqueous flare elevation after cataract surgery in humans. Aqueous flare elevation was induced either by application of prostaglandin E2(PGE2), 25μg/ml, to the cornea, or an intravenous injection of lipopolysaccharides(LPS), 0.5μg/kg, in pigmented rabbits. For pretreatment, about 150g/day of food containing Orengedoku-to, Senkanmeimoku-to, and Scutellariae radix was given to three groups of animals for 5 days before experimental uveitis was induced. Baicalein, baicalin, and wogonin, 60μg/kg or 600μg/kg, was injected into the ear vein 30 minutes before experimentaluveitis. Aqueous flare elevation induced by LPS wes significantly inhibited by pretreatment with Orengedoku-to, Senkanmeimoku-to, baicalein, baicalin, and wogonin. Aqueous flare elevation induced by PGE2 was significantly inhibited by pretreatment with Orengedoku-to, and Senkanmeimoku-to, but not with Scutellariaeradix, baicalein, baicalin, and wogonin.On clinical study, Kakkon-to and Orengedoku-to had inhibitory effects of aqueous flare elevation after cataract surgery.