Interaction between Gustatory and Olfactory Nerve Fiber-Circuits

味觉和嗅觉神经纤维回路之间的相互作用

• 批准号: 14571739
• 负责人: UEMURA Masanori
• 金额: $ 1.86万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571739/
• 关键词: main olfactory nucleus; accessory olfactory nucleus; rat; taste; bed nucleus of the stria terminalis; 味覚; 嗅覚; 嗅球; 外側嗅索; 神経回路; ラット

The present study intends to clarify a interaction of the taste and olfactory senses from the side of the neuronal fiber-circuits.Projections from the main or accessory olfactory' bulb were investigated by meas of studied in the rat by the tract-tracing methods with anterograde tracer(biotinylated dextran amine : BDA)and anterograde/retrograde tracer(wheat-germ agglutinin-horseradish peroxid ase : WGA-HRP)in the rat.After injection of the tracer into the main olfactory bulb, labeled terminal was observed at the anterior olfactory nucleus AON, tenia tecta TT, dorsal peducular cortex DPC・dorsal hippocampal ludiment DHR and olfactory terberculum Tu in the frontal cortex, the piriform cortex Pir, anterior amygdaloid cortex AACo, periamygdaloid cortex PeCo and entorhinal cortex Ent in the lateral cortex, and the nucleus of the lateral olfactory cortex and supraoptic nucleus in the nucleus.And, the labeled neurons appeared intheAON, DPC-DHR and Ent in the cortex, and the NLOT, DB, median raphe MnR、dorsal raphe nucleus DR and LC as the nucisus.Injecting into the accessory olfactory bulb, labelled fibers terminateed in the medial nucleus of the amygdala Me and posterior amygdaloid cortex PCo in the cortex, and the bed nucleus of the stria terminalis BST and nucleus of the accessory olfactory tract BAOT as the nucleus.And, labeled neurons were found in the medial division of AON AONm, BAOT, DB, lateral preoptic area LPO, DR and LC.

本研究用顺行追踪法研究了大鼠主嗅球和副嗅球的投射，旨在从神经纤维回路的角度阐明味觉和嗅觉的相互作用（生物素化葡聚糖胺：BDA）和顺行/逆行示踪剂（麦胚凝集素-辣根过氧化物酶：将示踪剂注入大鼠主嗅球后，在嗅前核AON、顶盖带TT、额叶皮质的背侧脚皮质DPC·背侧海马前体DHR和嗅间质Tu，外侧皮质的梨状皮质Pir、杏仁前皮质AACo、杏仁周皮质PeCo和内嗅皮质Ent，外侧嗅皮质的核和视上核。标记神经元出现在皮层的AON、DPC-DHR和Ent，NLOT、DB、中缝正中核MnR、中缝背核DR和LC为核团，向副嗅球注射，标记纤维终止于皮层的杏仁内侧核Me和杏仁后皮质PCo，终纹床核和副嗅束核BAOT为核团，AON内侧部、AONm、BAOT、DB、外侧视前区LPO、DR和LC均可见标记神经元。