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AGE-DEPENDENT CHNGES OF MOLECULR INTERACTION IN PERIODONTAL TISSUEU.

AGE-DEPENDENT CHNGES OF MOLECULR INTERACTION IN PERIODONTAL TISSUEU.
牙周组织中分子相互作用的年龄依赖性变化。
批准号:
14571851
负责人:
SAKAI Takako
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2004

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中文摘要
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英文摘要
We previously examined the age-dependent change of BrdU- and TUNEL-positive cells in the mouse periodontal tissue, and showed that a significant decrease of cellular component in association with aging occurred in the submucosal connective tissue caused by apoptosis. Based on this result, we also examined the cell kinetic change of various organs and tissues in mouse with aging. Decrease of BrdU-positive cells was observed in the epithelial layer of gingiva, buccal mucosa, skin and hair follicle at 30 weeks and following ages after birth. Meanwhile, increase of TUNEL-positive cell was demonstrated gingival submucosal tissue, and mucinous and serous acinar cells of submandibular gland at 20 weeks and following ages after birth. Thus age dependent change of the cell kinetic is evident in the gingival tissue, and is therefore seemed to be related with gingival recession.Senecent marker protein-30(SMP-30) is age-related marker protein, and is known to be expressed in brain and liver. SMP-30 is known to be related the apoptosis-resistant activity in cells. We examined the expression of SMP-30 in the mouse gingival tissue at 15 weeks after birth by RT-PCR. Furthernmore, we performed cDNA subtraction between 10 and 15 weeks aged mouse gingival tissue, and found that 68 genes in the 10 weeks, and 51 genes in the 15 weeks, were differentially expressed. Molecular interaction of SMP-30 and these differentially expressed genes are now proceeding.
期刊论文(4)
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Expression of heat shock proteins, Hsj2, Hsc73 and Hsp86 during the morphogenesis of the mouse lower first molar
小鼠下第一磨牙形态发生过程中热休克蛋白 Hsj2、Hsc73 和 Hsp86 的表达
DOI: --
发表时间: 2002
期刊: The Histochemical Journal 34(3-4)
影响因子: --
作者: [Hiroko Wada, et al.]
通讯作者: et al.
Research methodology for understanding "okashimi" in Japanese oral arts: From the viewpoint of cultural differences in humor
  • 批准号:
    26580025
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $1.91万
  • 财政年份:
    2014
  • 负责人:
    SAKAI Takako
  • 依托单位:
Developmental research for an online multiple branch adaptive diagnosis test of Japanese language ability for children with multilingual backgrounds
  • 批准号:
    25284092
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $7.9万
  • 财政年份:
    2013
  • 负责人:
    SAKAI Takako
  • 依托单位:
Research on the learning of Japanese humor by students of Japanese through watching rakugo performance
  • 批准号:
    23652028
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $1.75万
  • 财政年份:
    2011
  • 负责人:
    SAKAI Takako
  • 依托单位:
A Study ofTaxation onAffiliated Groups
  • 批准号:
    22730026
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $0.83万
  • 财政年份:
    2010
  • 负责人:
    SAKAI Takako
  • 依托单位:
海外基金