Analysis of the factor which promotes teeth eruption with using the dog model of mandibular allograft

利用犬同种异体下颌骨模型分析促牙萌出的因素

• 批准号: 14571886
• 负责人: YAMAGUCHI Munehiro
• 金额: $ 2.5万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571886/
• 关键词: tooth; eruption; aging; allograft; mandible; canine; dog; 歯牙萌出

Purpose: Aging is clinically related to tooth eruption; there are no known studies that have elucidated the relationship. We examined whether tooth eruption would occur normally in a mature subject. Materials and Methods: Using vascularized composite tissue mandibular transplantation, we extracted portions of immature mandibles including the tooth germs from young beagle dogs and placed them into unrelated immature and mature bejagle dogs. we examined eruption of lower first molar in the grafted mandibular bone and compared the results clinically, radiographically, and histologically.Results: Normal tooth eruption was observed in the transplanted mandibles in the young dogs. In the mature dogs, eruption from the gmungiva was delayed, Whereas that from alveolar bone occurred normally in the transplanted mandibles. Further, the whole crown was covered with a cap of gingival tissue in the mature dogs, although this cap was not gingival overgrowth.Conclusion: Tooth eruption is influenced by some unknown factors related to aging. Apparently, apotosis did not occur in the connective tissues between the reduced enamel epithelia and oral epithelia that overlay the teeth in the mature subjects.

目的：衰老在临床上与牙齿萌出有关;目前还没有已知的研究阐明这种关系。我们研究了牙齿萌出是否会发生在一个正常的成熟的主题。材料与方法：采用带血管蒂的下颌骨复合组织移植技术，我们从幼年比格犬的未成熟下颌骨中提取部分牙胚，并将其植入无关的未成熟和成熟比格犬体内。结果：移植的下颌骨中第一磨牙萌出正常，第一磨牙的萌出率为100%，第二磨牙的萌出率为100%。成年犬移植下颌骨的牙槽骨萌出延迟，而移植下颌骨的牙槽骨萌出正常。此外，在成年犬中，整个牙冠被牙龈组织覆盖，尽管这一覆盖不是牙龈过度生长。结论：牙齿萌出受一些与年龄有关的未知因素的影响。显然，细胞凋亡并没有发生在结缔组织之间的减少釉质上皮细胞和口腔上皮细胞覆盖的牙齿在成熟的主题。

项目成果

E.TANAKA, M.HAMAGUCHI, Y.EGUCHI, S.ISHII, T.OKAUCHI, T.AIKAWA, M.KOGO: "Influence of Aging on Tooth Eruption : Experimental Canine Mandibular Allograft"J.Oral and Maxillofacial Surgery. Vol.62 No.3. 353-360 (2004)

E.TANAKA、M.HAMAGUCHI、Y.EGUCHI、S.ISHII、T.OKAUCHI、T.AIKAWA、M.KOGO：“衰老对牙齿萌出的影响：实验性犬下颌同种异体移植”J.口腔颌面外科。

E.TANAKA, M.HAMAGUCHI, Y.EGUCHI, S.ISHII, T.OKAUCHI, T.AIKAWA, M.KOGO: "Influence of Aging on Tooth Eruption : Experimental Canine Mandikular Allograft"J.Oral and Maxillofacial Surgery. Vol.62 No.3. 353-360 (2004)

E.TANAKA、M.HAMAGUCHI、Y.EGUCHI、S.ISHII、T.OKAUCHI、T.AIKAWA、M.KOGO：“衰老对牙齿萌出的影响：实验性犬下颌同种异体移植”J.口腔颌面外科。

E.TANAKA, M.HAMAGUCHI, Y.EGUCHI, S.ISHII, T.OKAUCHI, T.AIKAWA, M.KOGO: "Influence of aging on tooth eruption: Experimental canine mandibular allograft."Journal of Oral and Maxillofacial Surgery.. Vol.62 No.3. 353-360 (2004)

E.TANAKA、M.HAMAGUCHI、Y.EGUCHI、S.ISHII、T.OKAUCHI、T.AIKAWA、M.KOGO：“衰老对牙齿萌出的影响：实验犬下颌同种异体移植。”口腔颌面外科杂志。