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Application of the three-dimensional jaw tracking system to mice and investigation of the jaw function using genetically engineered mouse.

三维颌骨跟踪系统在小鼠中的应用以及利用基因工程小鼠研究颌骨功能。

基本信息

批准号：
14571956
负责人：
KOGA Yoshiyuki
金额：
$ 2.24万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

・Collection of basic data of mouse jaw function (three-dimensional jaw movements and EMG).The three-dimensional jaw-tracking system was implanted in the normal mice. The jaw movement trajectories were recorded with foods in different texture : There were characteristic jaw movement patterns during mastication. The EMG recording were added to the system in order to investigate the mouse jaw function more in detail. Thus, jaw movement trajectories and masticatory muscle activities could be recorded simultaneously.・Evaluation of the acquisition of jaw function.To evaluate the acquisition of mouse's normal jaw function, the mice were divided into two groups. One group bred with solid food, and another group bred with liquid food. The jaw movement range of the liquid food group was smaller than that of the hard hood group and the characteristic EMG activity was found in the liquid food group.・Masticatory jaw movements and muscle activities of BDNF lacking mouseThe chewing pattern in BDNF lacking mice was more irregular and smaller than that of wild mice. During hard food chewing, the lateral jaw movement of BDNF lacking mice was restrict and the vertical jaw movement was increased.

・收集小鼠颌骨功能的基础数据（三维颌骨运动和肌电图）。将三维颌骨跟踪系统植入正常小鼠体内。记录不同质地食物的下颌运动轨迹：咀嚼过程中存在特征性的下颌运动模式。为了更详细地研究小鼠下颌功能，将肌电图记录添加到系统中。因此，可以同时记录下颌运动轨迹和咀嚼肌活动。・下颌功能获得的评估。为了评估小鼠正常下颌功能的获得，将小鼠分为两组。一组用固体食物喂养，另一组用液体食物喂养。液体食物组的下颌运动范围小于硬罩组，并且在液体食物组中发现了特征性肌电图活动。・BDNF 缺乏小鼠的咀嚼下颌运动和肌肉活动缺乏 BDNF 的小鼠的咀嚼模式比野生小鼠更不规则且更小。咀嚼硬食物时，BDNF缺失小鼠的下颌侧向运动受到限制，而垂直下颌运动增加。