Promotion of the bone resorption and formation with the low intensity pulsed ultrasound

低强度脉冲超声促进骨吸收和形成

• 批准号: 14571957
• 负责人: SOEJIMA Kazuhisa
• 金额: $ 2.3万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571957/
• 关键词: Low intensity pulsed ultrasound; Orthodontic force; osteoclast; shear stress; nitric o; blood flow; osteoblast; orthodontic tooth movement; 低周波超音波刺激

1.Changes of the bood flow in Periodontal Ligament by Low Intensity Pulsed Ultrasound(LIPUS)To investigate LIPUS reaches to the periodontal ligament, changes of the blood flow were observed with Tissue Oximeter. However, the significant changes of the bood flow by LIPUS were not observed.2.Effect of the LIPUS on NO production in osteoblast treated with pulsed fluid flow(PFF)To investigate LIPUS enhances the osteoblast activity treated with physiological stimulation, cultured osteoblasts were stimulated by LIPUS w/o pulsed fluid flow. NO production was enhanced by LIPUS and PFF simultaneous stimulation.3.Acceleration of the orthodontic tooth movement with LIPUSAcceleration of the orthodontic tooth movement with LIPUS were tested with histological evaluation in rat. LIPUS suppressed orthodontic tooth movement. In histological observation, bone resorption and the recruitment of the osteoclast were suppressed.In conclusion, LIPUS suppressed the orthodontic tooth movement because of the suppression of the bone resorption

1.低强度脉冲超声(LIPUS)对牙周膜血流的影响利用组织血氧仪观察LIPUS到达牙周膜的血流变化。2.LIPUS对脉冲液流(PFF)处理的成骨细胞产生NO的影响为研究LIPUS增强生理刺激条件下成骨细胞的活性，对体外培养的成骨细胞进行脉冲液流刺激。LIPUS和PFF同时刺激可促进正畸牙齿移动。3.LIPUS促进正畸牙移动用组织学方法检测LIPUS对正畸牙齿移动的促进作用。Lipus抑制正畸牙移动。在组织学观察中，LIPUS抑制了骨吸收和破骨细胞的募集。结论：LIPUS通过抑制骨吸收而抑制正畸牙移动

项目成果

Effects of pulsed electromagnetic field (PEMF) stimulation on bone tissue like formation are dependent on the maturation stages of the osteoblasts

• DOI: 10.1002/bem.10032
• 发表时间: 2002-07-01
• 期刊: BIOELECTROMAGNETICS
• 影响因子: 1.9
• 作者: Diniz, P;Shomura, K;Ito, G
• 通讯作者: Ito, G

Nitric oxide(NO) mediates the effects of pulsed electromagnetic field(PEMF) stimulation on the osteoblast proliferation and differentiation.

一氧化氮（NO）介导脉冲电磁场​​（PEMF）刺激对成骨细胞增殖和分化的影响。

• 发表时间: 2002
• 期刊: NITRIC OXIDE 7巻1号
• 作者: Diniz;P.;Soejima;K.;Ito;G.
• 通讯作者: G.

Diniz, P., Shomura, K., Soejima, K., Ito, G.: "Effects of pulsed electromagnetic field (PEMF) stimulation on bone tissue-like formation are dependent on the maturation stages of the osteoblasts."Bioelectromagnetics. 23巻5号. 398-405 (2002)

Diniz, P.、Shomura, K.、Soejima, K.、Ito, G.：“脉冲电磁场​​ (PEMF) 刺激对骨组织样形成的影响取决于成骨细胞的成熟阶段。”生物电磁学 23。第 5 卷。398-405 (2002)

Diniz, P., Soejima, K., Ito, G.: "Nitric oxide (NO) mediates the effects of pulsed electromagnetic field (PEMF)stimulation on the osteoblast proliferation and differentiation."Nitric Oxide. 7巻1号. 18-23 (2002)

Diniz, P.、Soejima, K.、Ito, G.：“一氧化氮 (NO) 介导脉冲电磁场​​ (PEMF) 刺激对成骨细胞增殖和分化的影响。”一氧化氮，第 7 卷，第 1 期。 18-23（2002）

Diniz, P., Soejima, K., Ito, G.: "Nitric oxide (NO) mediates the effects of pulsed electromagnetic field (PEMF) stimulation on the osteoblast proliferation and differentiation"NITRIC OXIDE. 7巻1号. 18-23 (2002)

Diniz, P.、Soejima, K.、Ito, G.：“一氧化氮 (NO) 介导脉冲电磁场​​ (PEMF) 刺激对成骨细胞增殖和分化的影响”一氧化氮，第 7 卷，第 1 期。 18-23 (2002)