Analysis of osteoclastogenesis regulated by orthodontic force

我们以前报道过破骨细胞前体细胞在骨组织中被检测为RANK阳性细胞。RANKL-/-鼠骨组织中可见RANK阳性细胞，而c-Fos-/-鼠骨组织中未见RANK阳性细胞。C-Fos，而不是RANKL，是破骨细胞前体上调RANK所必需的。然后，我们分析了c-Fos介导的破骨细胞前体RANK上调的机制。我们的结果表明，c-Fos不仅在RANKL诱导的破骨细胞的形成中起重要作用，而且在M-CSF诱导的破骨细胞前体的形成中也起重要作用。

We previously reported that osteoclast precursors were detected as RANK-positive cells in bone tissues. RANK-positive cells were observed in bone tissues in RANKL-/- mice, but not in c-Fos-/- mice. c-Fos, but not RANKL, is required for the up-regulation of RANK in osteoclast precursors. Then, we analyzed the mechanism of c-Fos-mediated up-regulation of RANK in osteoclast precursors. Our results suggest that c-Fos plays essential roles not only in RANKL-induced formation of osteoclasts but also in M-CSF-induced formation of osteoclast precursors.