The relationship between occiusal disharmony and hypothalamus in the rat

很少有神经内分泌学的研究考察了睡眠不和谐和压力之间的关系。为了确定睡眠不和谐对中枢神经系统的影响，我们测量了带和不带切帽的大鼠下丘脑室旁核附近血浆皮质酮和细胞外去甲肾上腺素。设置上限后，血浆皮质酮和细胞外去甲肾上腺素水平逐渐升高，分别在8.5小时和6.5小时达到峰值，之后下降。此外，无帽大鼠的血浆皮质酮和细胞外去甲肾上腺素水平在黑暗期开始前后以昼夜节律方式增加，而戴帽大鼠则没有。这些结果表明，睡眠不和谐导致了大鼠的慢性应激。

Few neuroendocrinological studies have examined the relationship between occiusal disharmony and stress. To determine the effect of occiusal disharmony on the central nervous system, we measured plasma corticosterone and extracellular noradrenaline in the vicinity of the hypothalamic paraventricular nucleus in rats with and without incisal caps.After setting the caps, plasma corticosterone and extracellular noradrenaline levels gradually increased, reaching a peak at 8.5 and at 6.5 hours respectively, after which they decreased.Furthermore, plasma corticosterone and extracellular noradrenaline levels increased in a circadian fashion around the onset of the dark phase in rats without caps, but not in rats with caps.These results suggest that occiusal disharmony causes chronic stress in the rat.