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The relationship between activation ofneurotransmitters by the mastication, learning, and memory : investigation of the mechanism by chronobiological method

咀嚼、学习和记忆激活神经递质之间的关系：通过时间生物学方法研究其机制

基本信息

批准号：
12672005
负责人：
YOSHIHARA Toshihiro
金额：
$ 1.73万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12672005/
关键词：
learning memory restricted daily feeding corticosterone

项目摘要

The purpose of the present study was to develop a new system for estimating the level of learning and memory of rats by chronobiological method, and to examine whether the mastication affects learning and memory.It is well known that the temporal profile of hypothalamus-pituitary-adrenocortical axis in rats are modified by restricted daily feeding (RF), in which food supply is restricted to a fixed time of day. Under RF, a corticosterone peak appears in 8 to 10 days, from 2 hours before the daily meal supply (anticipatory peak), and which is detectable for more than several weeks even after the termination of RF. The anticipatory corticosterone peak is regarded as an expression of endogenous circadian rhythm associated with the feeding schedule. In this study, this phenomenon was used for estimating the level of learning and memory of rats. The following results was obtained.(1) The anticipatory corticosterone peak did not appear under restricted daily parenteral feeding or under restricted daily nutrition via jugular vein. These results suggested that supplement nutrition was needed for the development of the anticipatory corticosterone peak.(2) Restricted daily solid meal produced the anticipatory hormone peak in 8 days, while restricted daily liquid meal produced the peak in 12 days. The developed hormone peak was less prominent by liquid meal than by solid.(3) The anticipatory corticosterone peak developed by solid meal persisted throughout the period examined (3 weeks) after the termination of RF, while the peak developed by liquid meal disappeared after the first week.It is concluded that liquid meal attenuates the meal anticipation in the adrenocortical activity in rats under RF. These results suggested that the mastication affected the development and persistence of memory in rats.

本研究的目的是建立一种新的时间生物学方法来评价大鼠的学习记忆水平，并探讨咀嚼是否影响学习记忆。在RF下，皮质酮峰值出现在8至10天内，从每日膳食供应前2小时开始（预期峰值），即使在RF终止后几周内也可检测到。预期的皮质酮峰值被认为是与摄食时间表相关的内源性昼夜节律的表达。本研究利用这一现象来评价大鼠的学习记忆水平。获得以下结果。(1)预期的皮质酮峰值并没有出现在限制每日胃肠外喂养或限制每日营养通过颈静脉。结果提示，皮质酮高峰期的出现需要补充营养。(2)限制每日固体膳食在8天内产生预期的激素峰值，而限制每日液体膳食在12天内产生峰值。液体餐的激素峰值不如固体餐显著。(3)预期的皮质酮峰值持续固体餐结束后RF检查的整个期间（3周），而峰值开发的液体餐消失后的第一week.It的结论是，液体餐减弱了RF下大鼠肾上腺皮质活动的膳食预期。提示咀嚼影响大鼠记忆的发展和持久性。