通过全基因组连锁分析鉴定高胆固醇血症和低α脂蛋白血症的易感基因-猫眼课题宝

通过全基因组连锁分析鉴定高胆固醇血症和低α脂蛋白血症的易感基因

批准号：

14572140

负责人：

KOBAYASHI Kimiko

金额：

$1.92万

依托单位：

University of Shizuoka (2003)University of Tsukuba (2002)

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2002

资助国家：

日本

项目状态：

已结题

起止时间：

2002 至 2003

来源：

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14572140/

关键词：

Quantitative-trait-locus genome-wide linkage search hypercholesterolemia hypoalphalipoproteinemia 脂質代謝異常 QTL連鎖解析

中文摘要

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英文摘要

We conducted a genome-wide linkage search for susceptibility gene influencing interindividual variation in serum lipid levels in a Japanese population. We have analyzed genotypic data of 352 microsatellite markers in 43 Japanese families (172 members) of probands with hypercholesterolemia. Quantitative-trait-locus (QTL) analysis for serum lipid levels was carried out by a Haseman-Elston method. We have observed significant LOD scores for the linkage of serum total cholesterol level on D3S1580, D11S935, and D15S120. In addition, we have observed significant in another 32 Japanese families (138 members). Only the linkage between serum total cholesterol level and D3S1580 have been ascertained. These data suggest that the chromosomal region around D3S1580 may be a susceptibility region influencing variation in total cholesterol level. Further investigation will be necessary to identify and test plausible candidate genes for hypercholesterolemia and hypoalphalipoproteinemia in this region.

期刊论文(30)

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会议论文

Yamakawa-Kobayashi K, Ishiguro H, Arinami T, Miyazaki R, Hamaguchi H.: "A Val227Ala polymorphism in the peroxisome proliferators activated receptor α(PPARA) gene is associated with variations in serum lipids levels."J.Med.Genet.. 39. 189-191 (2002)

Yamakawa-Kobayashi K、Ishiguro H、Arinami T、Miyazaki R、Hamaguchi H.：“过氧化物酶体增殖物激活受体 α (PPARA) 基因中的 Val227Ala 多态性与血清脂质水平的变化相关。”J.Med.Genet.. 39. 189-191 (2002)

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通讯作者：

Yamakawa-Kobayashi K, et al.: "Relation of the -514C/T polymorphism in the hepatic lipase gene to serum HDL an LDL cholesterol levels in postmenopausal women under hormone replacement therapy"Atheroscierosis. 162. 17-21 (2002)

Yamakawa-Kobayashi K 等人：“激素替代疗法下绝经后妇女肝脂肪酶基因中的 -514C/T 多态性与血清 HDL 和 LDL 胆固醇水平的关系”动脉粥样硬化。

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