Leukotrienes in nociceptive pathway and neuropathic pain.
Leukotrienes in nociceptive pathway and neuropathic pain.
批准号:
22700371
负责人:
KOBAYASHI Kimiko
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Leukotriene(LT) s belong to a large family of lipid mediators. LTs are known to be important factors in a variety of local and systemic diseases and allergic/inflammatory diseases. We examined whether LTs were implicated in neuropathic pain following peripheral nerve injury. Using the SNI model in rats, we investigated the expression of LT synthases and receptors mRNAs in the spinal cord and the roles on the pain behaviors. LTs and the receptors may be involved in the development of mechanical allodynia after peripheral nerve injury.
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DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[大久保正道, 山中博樹, 小林希実子, 野口光一]
通讯作者:
野口光一
DOI:
10.1002/glia.20948
发表时间:
2010-04-01
期刊:
GLIA
影响因子:
6.2
作者:
[Okubo, Masamichi, Yamanaka, Hiroki, Noguchi, Koichi]
通讯作者:
Noguchi, Koichi
DOI:
10.1186/1744-8069-8-8
发表时间:
2012-02-02
期刊:
Molecular pain
影响因子:
3.3
作者:
[Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K]
通讯作者:
Noguchi K
末梢神経損傷後に脊髄で増加する血小板活性化因子(PAF)は神経障害性疼痛に関与する
周围神经损伤后脊髓中的血小板激活因子(PAF)增加,与神经性疼痛有关
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大久保正道, 山中博樹, 小林希実子, 野口光一]
通讯作者:
野口光一
RhoA/ROCK pathway mediates morphological changes downstream of P2Y12/13 receptors in spinal microglia following peripheral nerve injury
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批准号:24500416
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:KOBAYASHI Kimiko
-
依托单位:
Interaction of genetic and environmental factors in the development of life-style-related diseases.
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批准号:19500602
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:KOBAYASHI Kimiko
-
依托单位:
The role of purinergic receptor in the spinal microglia following peripheral nerve injury
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批准号:19790159
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.32万
-
财政年份:2007
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负责人:KOBAYASHI Kimiko
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依托单位:
The studies for interactions between genetic and dietary factors in the development of Lifestyle-related disease.
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批准号:17500477
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:KOBAYASHI Kimiko
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依托单位:
Identification of the susceptive genes for hypercholesterolemia and hypoalphalipoproteinemia by Genome-wide linkage analysis
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批准号:14572140
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2002
-
负责人:KOBAYASHI Kimiko
-
依托单位:
Analysis of additive effects of common functional variants of candidate genes on the risk for coronary artery diseases
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批准号:12672197
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
-
负责人:KOBAYASHI Kimiko
-
依托单位:
海外基金