The studies for interactions between genetic and dietary factors in the development of Lifestyle-related disease.

研究遗传和饮食因素在生活方式相关疾病发展中的相互作用。

• 批准号: 17500477
• 负责人: KOBAYASHI Kimiko
• 金额: $ 2.24万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17500477/
• 关键词: lifestyle-related diseases; dietary factors; diabetes; obesity; hypertension; genetic polymorphism; カリウム摂取量; セリンスレオニンキナーゼ; 遺伝要因; エネルギー代謝; 活性酵素

Lifestyle-related diseases such as hypertension, diabetes, obesity and are very common in developed countries. The development of lifestyle-related diseases is related not only to lifestyle factors such as diet and exercise but also to genetic factors. The identification of genetic factors that contribute to such disease development is essential for establishing preventative methods.In the present study, we analyzed the genotypes of 36 single nucleotide polymorphisms (SNPs) in candidate genes for obesity, diabetes and hypertension in 835 apparently healthy people. The mean age of the subjects was 56.5±9.0 years. All visited medical clinics for routine medical check ups.At first, the relationships between BMI, blood pressure or occurrence of diabetes and these SNPs were analyzed. Statistically significant associations between BMI and SNPs of the UCP3 or ENPP1,between blood pressure and SNPs of the WNK1 or SLC12A1,and between diabetes and SNPs of the GSTM1,GSTM3 or CYBA the were observed (P<0.05). These data suggest that there are a number of genetic variants concerned in susceptibility for lifestyle-related diseases. In addition, we found a consistent interaction between a SNP in SLC12A1 and potassium intake in relation to blood pressure. In carriers with the C allele of SLC12A1,blood pressure increased as potassium intake decreased. Conversely, this increase was not presented in homozygous for the T allele. This data suggests that the interaction between a SNP in SLC12A1 and potassium intake is important in the determination of blood pressure. Further studies are required to clarify the interaction between genetic factors and dietary factors in the development of lifestyle-related diseases.

与生活方式有关的疾病，如高血压、糖尿病、肥胖症等，在发达国家非常常见。与生活方式有关的疾病的发展不仅与饮食和锻炼等生活方式因素有关，还与遗传因素有关。在本研究中，我们分析了肥胖、糖尿病和高血压候选基因中36个单核苷酸多态(SNPs)的基因型，并对835名看似健康的人进行了检测。受试者的平均年龄为56.5±9.0岁。首先分析体重指数、血压和糖尿病的发生与这些SNP的关系。BMI与UCP3或ENPP1的SNPs，血压与WNK1或SLC12A1的SNPs，糖尿病与GSTM1、GSTM3或Cyba的SNPs有统计学意义的相关性(P&lt；0.05)。这些数据表明，与生活方式相关疾病的易感性有关的基因变异有很多。此外，我们发现SLC12A1中的SNP与钾摄入量之间存在一致的相互作用，与血压有关。在携带SLC12A1 C等位基因的携带者中，血压随着钾摄入量的减少而升高。相反，T等位基因的纯合子没有表现出这种增加。这一数据表明SLC12A1中的SNP与钾摄入量之间的相互作用在血压测定中是重要的。需要进一步的研究来阐明遗传因素和饮食因素在与生活方式有关的疾病发展中的相互作用。