The studies for interactions between genetic and dietary factors in the development of Lifestyle-related disease.

与生活方式有关的疾病，如高血压、糖尿病、肥胖症，在发达国家非常普遍。生活方式相关疾病的发生不仅与饮食和运动等生活方式因素有关，还与遗传因素有关。在本研究中，我们分析了835名表面健康的人的36个单核苷酸多态性（SNPs）的基因型，这些基因在肥胖、糖尿病和高血压的候选基因中。受试者的平均年龄为56.5±9.0岁。首先分析这些SNPs与BMI、血压、糖尿病发生的关系。BMI与UCP3或ENPP1的SNP、血压与WNK 1或SLC 12A1的SNP、糖尿病与GSTM 1、GSTM 3或CYBA的SNP之间存在统计学显著性相关（P<0.05）。这些数据表明，有许多遗传变异与生活方式相关疾病的易感性有关。此外，我们发现SLC12A1中的SNP和钾摄入量与血压之间存在一致的相互作用。在携带SLC12A1的C等位基因的携带者中，血压随着钾摄入量的减少而升高。相反，这种增加在T等位基因纯合子中不存在。这些数据表明，SLC12A1中的SNP与钾摄入量之间的相互作用在血压测定中很重要。需要进一步的研究来阐明遗传因素和饮食因素在生活方式相关疾病发展中的相互作用。

Lifestyle-related diseases such as hypertension, diabetes, obesity and are very common in developed countries. The development of lifestyle-related diseases is related not only to lifestyle factors such as diet and exercise but also to genetic factors. The identification of genetic factors that contribute to such disease development is essential for establishing preventative methods.In the present study, we analyzed the genotypes of 36 single nucleotide polymorphisms (SNPs) in candidate genes for obesity, diabetes and hypertension in 835 apparently healthy people. The mean age of the subjects was 56.5±9.0 years. All visited medical clinics for routine medical check ups.At first, the relationships between BMI, blood pressure or occurrence of diabetes and these SNPs were analyzed. Statistically significant associations between BMI and SNPs of the UCP3 or ENPP1,between blood pressure and SNPs of the WNK1 or SLC12A1,and between diabetes and SNPs of the GSTM1,GSTM3 or CYBA the were observed (P<0.05). These data suggest that there are a number of genetic variants concerned in susceptibility for lifestyle-related diseases. In addition, we found a consistent interaction between a SNP in SLC12A1 and potassium intake in relation to blood pressure. In carriers with the C allele of SLC12A1,blood pressure increased as potassium intake decreased. Conversely, this increase was not presented in homozygous for the T allele. This data suggests that the interaction between a SNP in SLC12A1 and potassium intake is important in the determination of blood pressure. Further studies are required to clarify the interaction between genetic factors and dietary factors in the development of lifestyle-related diseases.