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Aquatic exercise in hypobaric hypoxic environment for the lifestyle-related disease improvement

低压低氧环境下的水中运动改善生活方式相关疾病

基本信息

批准号：
16500446
负责人：
OGITA Futoshi
金额：
$ 2.24万
依托单位：
National Institute of Fitness and Sports
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500446/
关键词：
life related disease hypobaric hypoxic environment aquatic environment exercise therapy cardiovascular function glucose metabolism fat metabolism

项目摘要

Present study aimed to establish a beneficial exercise therapy for lifestyle-related disease improvement, determining the effects of aquatic exercise in hypobaric hypoxic environment gives on cardiovascular response, glucose and fat metabolism.Healthy 3 young adult groups, A (n=6), B (n=6), C (n=6), and middle-aged group D (n=5) performed an aquatic exercise at the intensity of around 50%VO2max for 30 min/session, for 4 weeks. A, B and D were exposed to hypoxic condition corresponding to 2000m and C was exposed to 2500m above sea level for 2.5hours/session. The training frequency was 4 times/week in A and 3 times/week in B, C and D. Before and after the training period, VO_2max and cardiovascular responses such as heart rate (HR), stroke volume (SV), cardiac output (CO), and systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) during cycling exercise at the intensity of 50%VO_2max, which was determined before the training, were measured.After the 4 weeks of training, VO_2max did not change significantly in all groups. In cardiovascular responses during the moderate exercise, no significant changes were observed in B and D. On the other hand, SV and CO in A and C significantly increased. In addition, a significant decrease was observed in DBP and MBP in A and C. Also, after the oral glucose tolerance test, under-curve area and blood insulin concentration by 120 min were significantly reduced only in C. In blood lipid, total cholesterol and LDL were significantly decreased in A and B, but not in C and D. A significant decrease was observed in skinfold thickness in A, B and C, but not D. Taken all, our results revealed that an aquatic exercise in hypobaric hypoxic environment would induce more effectively the beneficial changes in cardiovascular function, glucose and fat metabolism. These new findings would open the positive possibilities of utilizing hypoxia with exercise for prevention and clinical treatment of lifestyle-related disease.

本研究旨在建立一种改善生活方式相关疾病的有益运动疗法，以确定低压低氧环境下水上运动对心血管反应、糖脂代谢的影响。健康青年组A组(n=6)、B组(n=6)、C组(n=6)和中年组D组(n=5)进行50%最大摄氧量的水上运动，每次30min，持续4周。A、B、D暴露于2000m的低氧条件下，C暴露于海拔2500m的低氧条件下2.5h/次。A组每周训练4次，B、C、D组每周训练3次，测试训练前后心率(HR)、每搏输出量(SV)、心输出量(CO)以及训练前测定的50%VO2max强度自行车运动时的心率(HR)、每搏输出量(SV)、心输出量(CO)、收缩压(SBP)、舒张压(DBP)和平均血压(MBP)等心血管反应。在中等强度运动的心血管反应中，B组和D组无明显变化，而A组和C组的SV和CO显著增加。口服葡萄糖耐量试验后，曲线下面积和120min血胰岛素浓度仅C组显著降低。在血脂方面，A、B组总胆固醇和低密度脂蛋白显著降低，而C组和D组无明显变化。A、B、C组皮脂厚度显著降低，D组无。综上所述，低氧环境下的水上运动能更有效地引起心血管功能、糖脂代谢的有益变化。这些新的发现将开启利用低氧和运动预防和临床治疗与生活方式相关的疾病的积极可能性。