The influence of postprandial hyperlipidemia and exercise on the oxidative stress

我们研究了口服脂肪乳膏对健康男女学生餐后脂代谢的影响。血清总甘油三酯和甘油三酯残留量高峰时男性高于女性，峰值后总甘油三酯和残留甘油三酯下降速度慢于女性。结果表明，与女性相比，男性肝脏中残留物的产生可能更多，或者循环中残留物的清除可能会延迟。然后，我们以高中游泳运动员为对象，研究了运动(游泳)对氧化应激和抗氧化状态的影响。运动过程中抗氧化状态(生物抗氧化潜能，BAP)呈递增趋势，运动后恢复到基线水平。在检查期间，没有观察到氧化应激(活性氧代谢物，droms)的显著变化。血清乳酸浓度随运动增加而增加，与BAP显著相关。结果提示，日常训练可提高机体的抗氧化能力，保护机体免受活性氧和自由基的损伤。接下来，我们研究了运动和吸烟对健康青年学生脉搏波速度和心动过速的影响。男性吸烟者的PWV高于不吸烟者，而女性吸烟者与不吸烟者的PWV差异无统计学意义。即使在年轻人中，吸烟也可能对心血管系统产生有害影响，良好的生活方式应该从年轻人开始。

We studied the effects of oral fat cream administration on postprandial lipid metabolism, using healthy male and female students. Serum total triglyceride and remnant triglyceride were higher at the peak in males than in females, and the decrease of total and remnant triglyceride after the peak was slower in males than in females. The results suggest that the production of remnants in the liver may be higher or the clearance of remnants from the circulation may be delayed in males compared with females. Then we examined the influence of exercise (swimming) on the oxidative stress and anti-oxidant status, using high-school swimmers. During exercise, anti-oxidant status (Biological antioxidant potential, BAP) increased progressively, and returned to the base line after the exercise. No significant changes of oxidative stress (Reactive oxygen metabolites, dROMs) were observed during the examination period. Serum lactate concentrstions were incresed associated with exerecie and significantly correlated with the BAP. The results suggest that the daily training increases anti-oxidant status and protects the body from the damage by active oxygen and free radicals. Next, we examined the influence of exercise and smoking on the pulse wave velocity and CAVI in young healthy students. Male smokers had higher PWV compared with non-smokers, but in female smokers no significant diffrence was observed between smokers and non-smokers. Even in young people, smoking may have deleterious influence on the cardiovascular system, and the good lifestyle should be started from the young.