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Development of biodegradable polymers that can recognize microorganisms

开发可识别微生物的生物可降解聚合物

基本信息

批准号：
16510068
负责人：
OSAWA Satoshi
金额：
$ 1.6万
依托单位：
Kanazawa Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

The goal on this research is to prepare biodegradable polymer that have ability of recognition for microorganisms. For the purpose, we have prepared various microscopic patterns with different size on the surface of biodegradable polymers. It was fond that the polymer surface recognized fungi by controlling the micro-scale size of porous structure and regularly aligned concavity and convexity structures.Smooth biodegradable polymer surface did not adsorb any type of fungi. On the other hand, fungi was strongly adsorbed to the concavity and convexity structure with the cross pitch of 30μm x 30μm. Producing the water repellent surface onto biodegradable polymer must result in some new functions. The antibacterial property may also be obtained by the water repellency on the biodegradable polymer surface. Among water repellent natural leaves, we have chosen a structure of aroid leaf for preparing super-hydrophobic surface on biodegradable sheet since it has high water contact angle and the concavity-pattern is thought to be enough handle for a material use. Transcribing aroid structure gave 30μm ordered concavity-pattern on biodegradable polymer surface and the solvent treatment resulted in sub-micrometer ordered roughness.The water repellent natural leaves usually have antibacterial property due to the prevention of water. To investigate the antibacterial property, the transcribed biodegradable samples were soaked into fungus culture having isolated Asperugillus sp and E.coli. The filamentous fungus and bacteria did not grow on the transcribed surface with solvent treatment. The results suggested that combination of two ordered structures, i.e. several micrometer and sub-micrometer patterns recognize microorganisms.

本研究的目标是制备具有微生物识别能力的可生物降解聚合物。为此，我们在可生物降解聚合物的表面制备了各种不同尺寸的微观图案。人们发现聚合物表面通过控制多孔结构和规则排列的凹凸结构的微观尺寸来识别真菌。光滑的可生物降解聚合物表面不吸附任何类型的真菌。另一方面，真菌强烈吸附在交叉节距为30μm×30μm的凹凸结构上。在可生物降解的聚合物上生产防水表面必然会带来一些新的功能。抗菌性能还可以通过生物可降解聚合物表面的拒水性来获得。在防水的天然叶子中，我们选择了天南星叶子的结构，在可生物降解的片材上制备超疏水表面，因为它具有高水接触角，并且凹形图案被认为足以满足材料使用的手感。转录类环状结构在可生物降解聚合物表面形成30μm有序凹面图案，溶剂处理产生亚微米有序粗糙度。疏水性天然叶子通常由于防水而具有抗菌性能。为了研究抗菌特性，将转录的可生物降解样品浸泡到分离有曲霉菌和大肠杆菌的真菌培养物中。经过溶剂处理的转录表面上丝状真菌和细菌没有生长。结果表明，两种有序结构（即几个微米和亚微米图案）的组合可以识别微生物。