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Development of biodegradable polymers that can recognize microorganisms

开发可识别微生物的生物可降解聚合物

基本信息

批准号：
16510068
负责人：
OSAWA Satoshi
金额：
$ 1.6万
依托单位：
Kanazawa Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

The goal on this research is to prepare biodegradable polymer that have ability of recognition for microorganisms. For the purpose, we have prepared various microscopic patterns with different size on the surface of biodegradable polymers. It was fond that the polymer surface recognized fungi by controlling the micro-scale size of porous structure and regularly aligned concavity and convexity structures.Smooth biodegradable polymer surface did not adsorb any type of fungi. On the other hand, fungi was strongly adsorbed to the concavity and convexity structure with the cross pitch of 30μm x 30μm. Producing the water repellent surface onto biodegradable polymer must result in some new functions. The antibacterial property may also be obtained by the water repellency on the biodegradable polymer surface. Among water repellent natural leaves, we have chosen a structure of aroid leaf for preparing super-hydrophobic surface on biodegradable sheet since it has high water contact angle and the concavity-pattern is thought to be enough handle for a material use. Transcribing aroid structure gave 30μm ordered concavity-pattern on biodegradable polymer surface and the solvent treatment resulted in sub-micrometer ordered roughness.The water repellent natural leaves usually have antibacterial property due to the prevention of water. To investigate the antibacterial property, the transcribed biodegradable samples were soaked into fungus culture having isolated Asperugillus sp and E.coli. The filamentous fungus and bacteria did not grow on the transcribed surface with solvent treatment. The results suggested that combination of two ordered structures, i.e. several micrometer and sub-micrometer patterns recognize microorganisms.

本研究的目的是制备对微生物具有识别能力的生物可降解聚合物。为此，我们在生物可降解聚合物表面制备了各种不同尺寸的微观图案。研究发现，可生物降解聚合物表面通过控制微尺度的多孔结构和规则排列的凹凸结构来识别真菌，光滑的可生物降解聚合物表面不吸附任何类型的真菌。另一方面，真菌强烈吸附在交叉间距为30μm × 30μm的凹凸结构上。在可生物降解的聚合物上产生防水表面必然会产生一些新的功能。抗菌性能也可以通过生物可降解聚合物表面上的拒水性获得。在防水的天然叶子中，我们选择了一种用于在可生物降解的片材上制备超疏水表面的天南星叶结构，因为它具有高的水接触角，并且认为凹面图案对于材料使用来说是足够的处理。通过转录类胡萝卜素结构，在生物可降解聚合物表面形成了30μm的有序凹凸结构，而溶剂处理则形成了亚微米级的有序粗糙结构。为了研究抗菌性能，将转录的生物可降解样品浸泡到具有分离的铜绿假单胞菌和大肠杆菌的真菌培养物中。丝状真菌和细菌在溶剂处理的转录表面上不生长。结果表明，两种有序结构的组合，即几个微米和亚微米模式识别微生物。