Development of Novel "Nonamphiphilic" Polymeric Micelles

新型“非两亲性”聚合物胶束的开发

• 批准号: 16510086
• 负责人: YOSHIDA Eri
• 金额: $ 2.11万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16510086/
• 关键词: "Nonamphiphilic" polymers; Polymeric micelles; Spherical nanoparticles; Noncovalent bond cross-linking; Block copolymers; Random copolymers; Critical micelle concentration; Functional nanoparticles; 非両親媒性"高分子; ミセル形成; 超微粒子; ナノ染料分子; ナノ粒子化; 紫外線吸

We found novel micelle formation of "nonamphiphilic" polymers consisting entirely of solvophilic segments and developed new polymeric materials using the micelle formation. We prepared nonamphiphilic block copolymers and random copolymers having electron-donating groups at the side chains. The copolymers showed no self-assembly by themselves. The light scattering studies demonstrated that the copolymers formed spherical micelles with a nanoscale in the presence of additives which have an interaction or promote salt formation with the side groups of the copolymers. The size and aggregation numbers of the micelles were dependent on the molecular weight of the polymers, the functionality and structure of the additives, indicating that the size and aggregation numbers of the micelles could be controlled by these factors. We also explored the thermodynamics and kinetics of the micellization and determined the enthalpy and entropy of the micelle formation. Furthermore, we succeeded in preparing functional nanoparticles through the micelle formation of block copolymers with functional groups. The micellization of block copolymers with dye molecules and UV absorbents produced highly light-stable nanodyes.

我们发现了新的胶束形成的“非两亲性”聚合物完全由亲溶剂链段组成，并开发了新的聚合物材料使用胶束形成。我们制备了非两亲性嵌段共聚物和侧链含有供电子基团的无规共聚物。共聚物本身没有表现出自组装。光散射研究表明，在添加剂的存在下，共聚物形成了具有纳米尺度的球形胶束，所述添加剂与共聚物的侧基具有相互作用或促进成盐。胶束的大小和聚集数取决于聚合物的分子量、添加剂的官能度和结构，表明胶束的大小和聚集数可以由这些因素控制。我们还探讨了胶束化的热力学和动力学，并测定了胶束形成的焓和熵。此外，我们成功地制备功能性纳米粒子通过胶束形成的嵌段共聚物与功能基团。嵌段共聚物与染料分子和紫外线吸收剂的胶束化产生高度光稳定的纳米染料。

项目成果

Thermodynamics and kinetics on micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene by α, ω-Dia mine

α, ω-Dia 矿形成非两亲性聚(乙烯基苯酚)-嵌段-聚苯乙烯胶束的热力学和动力学

• 发表时间: 2005
• 期刊: Colloid Polym. Sci 284
• 作者: Eri Yoshida;Shinichi Itsuno
• 通讯作者: Shinichi Itsuno

Reversible Control of Miceillization Induced by Hydrogen Bond Cross-Linking for a Nonamphiphilic Diblock Copolymer with an α,ω-Diamine

非两亲性二嵌段共聚物与 α,ω-二胺的氢键交联诱导的胶束化的可逆控制

• 期刊: Polym.Adv.Technol. 印刷中
• 作者: E.Yoshida;M.Ohta;Y.Terada
• 通讯作者: Y.Terada

高分子集合体からなる球状微粒子及びその微粒子の製造方法

由聚合物聚集体制成的球形细颗粒及其制造方法

• 发表时间: 2006

Control of Self-Assembly by Perfluorinated Counter Anions in Salt-Induced Micellization of a Pyridine-Containing Diblock Copolymer

含吡啶二嵌段共聚物盐诱导胶束化过程中全氟抗衡阴离子对自组装的控制

• 发表时间: 2004
• 期刊: Am.Chem.Soc., Polymer Preprint 45(1)
• 作者: E.Yoshida;M.Tanaka;T.Takata
• 通讯作者: T.Takata

Reversible Control of Micellization Induced by Hydrogen Bond Crosslinking for a Nonamphiphilic Diblock Copolymer with an a,ω-Diamine

非两亲性二嵌段共聚物与 a,ω-二胺的氢键交联诱导的胶束化的可逆控制

• 发表时间: 2005
• 期刊: Polym. Adv. Technol. 16
• 作者: E.Yoshida;M.Ohta;Y.Terada
• 通讯作者: Y.Terada