Molecular epidemiology of Candida albicans

白色念珠菌的分子流行病学

• 批准号: 16510176
• 负责人: TANAKA Reiko
• 金额: $ 2.24万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16510176/
• 关键词: pathogenic fungi; Candida albicans; genotype; molecular epidemiology; antifungal agent; 病原性酵母; 薬剤感受性; カンジダ・アビカンス

For a molecular epidemiology analyses of Candida albicans, more than 1000 strains of C.albicans were genotyped using two methods (25S genotype and ALTS). The ratio of the 25S genotypes (A, B, C) and ALTS were compared by country (Japan, Brazil, Thailand). In Thailand, the ratio of genotypes B and C was higher than that of Japan and Brazil. In ALTS, it was divided into at least 13 types, and a peculiar pattern to each country was shown. This result showed a geographical specificity of C.albicans.On the other hand, when the isolation source was analyzed as skin origin, mouth origin, and internal organs origin, a lot of genotype B turned out internal organs origin strains in Brazil and Thailand. Many of internal organs origin strains of Brazil and Thailand were isolated from the AIDS patient, and the relation between genotype B and AIDS was shown. In the antifungal susceptibility, a strong relation to 25S genotypes was not shown. However, because the azole resistance had been shown with a part of genotypes B and C strain, it seemed that the relation to AIDS was supported.

为了对白色念珠菌进行分子流行病学分析，使用两种方法（25S 基因型和 ALTS）对 1000 多株白色念珠菌进行了基因分型。按国家（日本、巴西、泰国）比较 25S 基因型（A、B、C）和 ALTS 的比例。在泰国，B型和C型基因的比例高于日本和巴西。在ALTS中，它被分为至少13种类型，并显示出每个国家特有的模式。这一结果显示了白色念珠菌的地理特异性。另一方面，当分离源分析为皮肤来源、口腔来源和内脏来源时，大量B基因型在巴西和泰国变成了内脏来源菌株。从艾滋病患者身上分离到许多巴西和泰国的内脏来源菌株，显示了B基因型与艾滋病之间的关系。在抗真菌敏感性方面，未显示与 25S 基因型的密切关系。然而，由于部分基因型B和C菌株已显示出唑类抗性，因此似乎支持与艾滋病的关系。

项目成果

Evaluation of a newly developed identification kit, RID Zyme CAS test, for Candida albicans

评估新开发的白色念珠菌鉴定试剂盒 RID Zyme CAS 测试

• 发表时间: 2005
• 期刊: Jpn J Med Mycol 46・2
• 作者: Tanaka R;Ito J;Sato A;Nishimura K
• 通讯作者: Nishimura K

Evaluation of a newlydeveloped indentification kit, RID Zyme CAS test, for Candida albicans.

评估新开发的白色念珠菌鉴定试剂盒 RID Zyme CAS 测试。

• 发表时间: 2005
• 期刊: 日本医真菌学会雑誌 46巻2号
• 作者: Reiko Tanaka;Junko Ito;Ayaka Sato;Kazuko Nishimura
• 通讯作者: Kazuko Nishimura

Evaluation of a newly developed identification kit, RID Zyme CAS test, for Candida albicans.

评估新开发的白色念珠菌鉴定试剂盒 RID Zyme CAS 测试。

• 发表时间: 2005
• 期刊: Jpn J Med Mycol 46(2)
• 作者: Tanaka R;Ito J;Sato A;Nishimura K
• 通讯作者: Nishimura K