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Analysis of Extraction Mechanism of Airflow Information in the Cricket Cercal Sensory System

蟋蟀尾部感觉系统气流信息提取机制分析

基本信息

批准号：
16570068
负责人：
OGAWA Hiroto
金额：
$ 2.37万
依托单位：
Saitama Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

The aim of this project is to elucidate the neural process of extraction and integration of directional information of air current in the cricket cercal sensory system, using calcium imaging and electrophysiological techniques. In 2004, the calcium imaging of the mechanosensory afferent neurons demonstrated that air-current stimuli from different directions induced different spatial patterns of Ca^<2+> elevation in the terminal arbors of sensory afferents within the terminal abdominal ganglion. To characterize the spatial patterns of the air-current-evoked ensemble activity of afferents, the optically-recorded responses to the repeated air-current stimuli from different directions were averaged and filtered. Based on the averaged image, we derived activity-pattern maps representing the direction of air current within the afferent projection. In 2005, we simultaneously monitored the Ca^<2+> responses to air-current stimuli at the dendrites of the identified giant interneurons (Gls) and … More the mechanosensory afferent terminals having synaptic connections on that dendritic branch. And, we compared the directional tuning properties of the postsynaptic GIs 10-2 and 10-3, which have different dendritic arborization pattern. The results suggest that the individual dendrite of 10-3 extracts distinct directional sensitivities from presynaptic afferents in the local region occupied by that dendritic branch. On the other hand, the dendrites of 10-2 extracts the directional information represented by ensemble activity patterns within the afferent projection. Since the electrotonic distances from the spike-initiating zone (SIZ) to each dendrite in 10-3 vary from each other, the directional sensitivity extracted by the nearest dendrite from SIZ will dominate the tuning properties of the voltage responses. In 10-2, the electrotonic distances from SIZ to each dendrite were close to each other. Therefore, the directional sensitivity extracted by all dendrites will be reflected to the overall tuning properties under the same weight. It is possible that the differences in the distribution of synaptic weights due to the dendritic geometry may be related to algorithm for the extraction and integration of the sensory information in the postsynaptic interneurons. Less

本研究的目的是利用钙离子成像和电生理技术，阐明蟋蟀颈感觉系统中气流方向信息的提取和整合的神经过程。2004年，机械感觉传入神经元的钙成像显示，来自不同方向的气流刺激在终末腹神经节内的感觉传入终末支中诱导不同的Ca^2+升高空间模式。为了表征传入的气流诱发的集合活动的空间模式，对来自不同方向的重复气流刺激的光学记录的反应进行平均和过滤。基于平均图像，我们推导出活动模式图表示传入投射内的气流方向。在2005年，我们同时监测了已鉴定的巨中间神经元（Gls）树突对气流刺激的Ca^<2+>反应， ...更多信息机械感觉传入末梢在该树突分支上具有突触连接。并且，我们比较了具有不同树突分支模式的突触后神经元10-2和10-3的定向调谐特性。结果表明，10-3的单个树突提取不同的方向敏感性突触前传入的局部区域所占领的树突分支。另一方面，10-2的树突提取由传入投射内的集合活动模式表示的方向信息。由于从尖峰起始区（SIZ）到10-3中每个枝晶的电紧张距离彼此不同，因此由SIZ最近的枝晶提取的方向灵敏度将主导电压响应的调谐特性。在10-2中，SIZ到每个树突的电紧张距离彼此接近。因此，所有树突提取的方向灵敏度将反映到相同权重下的整体调谐性能。由于树突几何形状导致的突触权重分布的差异可能与突触后中间神经元中感觉信息的提取和整合算法有关。少