Brain development and evolution from the aspect of cerebrovascular reactivity and drug distribution of receptor subtypes

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1. Adrenoceptor a and 5-HTi receptor subtypes might be important in arterial contraction in snake basilar artery. Endothelial cells might play an important role in the responsiveness of snake basilar arteries to rattlesnake BK, but they might not be involved in the responsiveness to ACh, BK and resting vascular tone.2. NO may inhibit COX or TXA_2 synthetase, and that therefore inhibition of NOS might disinhibit COX or TXA_2 synthetase, subsequently inducing TXA_2 production in porcine basilar arterial endothelial cells. On the other hand, as TXA_2 and other contractility-related prostaglandin(s) may inhibit NOS, therefore the inhibition of COX or TXA_2 synthetase might disinhibit NOS, and then increase the spontaneous production of NO.3. The contraction induced by Ang II might be mediated via the activation of ATi receptors on the porcine basilar arterial smooth muscle cells and be modulated via the activation of AT_2 receptors on the endothelial cells, followed by NO production.4. Endotoxin enhances NO production in Mg-deficient rat aortas directly, and that endotoxin receptors might, at least in part, contribute to this enhancement.