Studies of the expression and regulation of the intercellular channel proteins in cardiac excitation-contraction coupling.

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We analyzed the expression, phosphorylation, and localization of the major cardic gap-junction protein connexin 43 during the establishment of a synchronized contraction in confluent monolayrs of primary cultured neonatal rat cardiac myocytes, combined with a functional assay of gap junctions by the microinjection-dye transfer method. The findings suggested that a concerted action of the expression, phosphorylation, and localization of connexin 43 and gap-junctional intercellular communication plays a major role in the reestablishment of synchronous beating of cultured neonatal rat cardiac myocyte. (Exp. Cell Res., 212,351-358,1994)