Longitudinal data analysis of health examination data in Nagasaki atomic bomb survivors

本研究的目的是探讨原子弹爆炸幸存者的健康检查数据的长期趋势。绝经后妇女骨密度的纵向研究1994年5月至1995年4月，对195名年龄在50 - 69岁之间的社区妇女进行了基线调查。采用双能X线骨密度仪测量腰椎前后位（L2 ~ L4）骨密度。直到2004年4月，我们重复测量BMD。每例受试者的平均测量次数为3.1次，平均随访时间为5.4年。在基线时年龄为50-54岁的患者（从0.862降至0.814）和55-59岁的患者（从0.807降至0.791）中观察到BMD显著降低，而60-69岁的患者BMD无显著变化。线性回归分析证实BMD随年龄的增加呈二次曲线下降，而绝经年限、BMI和生活方式因素对BMD的下降无显著影响.原子弹爆炸后白血病、淋巴瘤、骨髓瘤死亡者体检资料的长期趋势研究对象为502名原子弹爆炸后死于白血病、淋巴瘤、骨髓瘤的幸存者（急性白血病94人，慢性白血病86人，其他类型白血病50人，淋巴瘤63人，骨髓瘤70人，其他139人）。采用纵向数据分析方法分析白色细胞计数、血尿酸、乳酸脱氢酶和C反应蛋白的长期变化趋势。确定了健康检查数据的疾病特定纵向模式。急性白血病患者白细胞计数随死亡的临近而下降，而慢性白血病患者白细胞计数随死亡的临近而升高。在淋巴瘤或恶性肿瘤患者中，WBC计数在2，000至10，000（/μL）范围内波动。

The objective of the present study was to investigate secular trends of health examination data in atomic bomb survivors.1. Longitudinal Study of Bone Mineral Density among Postmenopausal WomenA total of 195 community-dwelling women, aged from 50 to 69 years, underwent a baseline survey between May 1994 and April 1995. The bone mineral density (BMD) of anterior-posterior lumbar spine (L2-L4) was measured by dual-energy X-ray absorptiometry. We measured BMD repeatedly until April 2004. The mean number of measurements for each subject was 3.1 times and the mean length of follow-up was 5.4 years. A significant reduction in BMD was observed in those who were aged 50-54 years at the baseline (from 0.862 to 0.814) and in those who were aged 55-59 (from 0.807 to 0.791), while BMD did not change significantly in those who were aged 60-69. Linear regression analysis confirmed that BMD reduced quadratically with age, however years since menopause, BMI and lifestyle factors did not have significant impact on the reduction in BMD.2. Secular Trends of Health Examination Data in Atomic Bomb Survivors Who Died from Leukemia, Lymphoma and MyelomaThe study subjects were 502 atomic bomb survivors who died from leukemia, lymphoma and myeloma (acute leukemia 94, chronic leukemia 86, other types of leukemia 50, lymphoma 63, myeloma 70, and others 139). Secular trends of white blood cell (WBC) counts, serum uric acid, lactate dehydrase and C-reactive protein were analyzed by using longitudinal data analysis methods. Disease specific longitudinal pattern of health examination data were identified. The WBC counts were decreasing with approaching toward the death in the acute leukemia patients, while the WBC counts were increasing in the chronic leukemia patients. In patients of lymphoma or meyloma, the WBC counts fluctuated within a range of 2,000 to 10,000 (/μL).