Relation of the postmortem elapsed time in alcohol and stimulants compound intoxication, and a drug level.

酒精和兴奋剂化合物中毒的死后时间与药物水平的关系。

• 批准号: 16590547
• 负责人: MAKOTO Nihira
• 金额: $ 2.11万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590547/
• 关键词: ethanol; ethyl glucuronide; methamphetamine; simultaneous administration; postmortem; metabolism of methamphetamine; glucuronate conjugation; rat; メタンアンフェタミン代謝物

A part of ethanol becomes ethyl glucuronide in response to glucuronate conjugation. It is said that ethyl glucuronide which can be detected at a long period of time rather than ethanol is detected, is effective in the proof of drinking. On the other hand, a psycho-stimulant is called third following abuse term, and abuse of the younger age group poses a problem. Methamphetamine is melted to alcohol.Then, methamphetamine is administered intraperitoneally with the dose of 5mg/kg to the rats and ethanol was administered orally to the rat with the dose of 4g/kg and methamphetamine and ethanol simultaneously to the rats, and the influence on the metabolism to ethanol and methamphetamine metabolism was considered this time. After administration of ethanol, methamphetamine, ethanol and methamphetamine simultaneous administration, rats were left from the 1st to the 7th in 20℃ incubator and ethanol, ethyl glucuronide, methamphetamine, and metabolites were measured.Ethanol, both in an ethanol ad … More ministration group, and a methamphetamine simultaneous administration group was not detected from serum and urine after 24 hours. Ethyl glucuronide was detected from serum and urine at 24hours after administration of ethanol and methamphetamine simultaneous administration. This result shows that measurement of ethyl glucuronide is effective in the proof of drinking. The concentration of ethyl glucronide in liver, kidney and brain was not influenced by methamphetamine simultaneous administration. On the other hand, the metabolizm of methamphetamine was influenced by ethanol simultaneous administration. Especially, the generation of p-hydroxy metabolites was reduced by ethanol simultaneous administration.Ethanol was detected from liver, kidney and brain at 7days after postmortem. Ethanol at 7 days after postmortem was detected approximately as much as that at 1day. There was no difference between the concentration of ethyl glucronide in liver, kidney and brain of ethanol group and that of methamphetamine simultaneous administration group. Less

一部分乙醇在葡萄糖醛酸结合反应中变成乙基葡萄糖醛酸苷。据说，乙基葡萄糖醛酸苷可以在很长一段时间内检测到，而不是检测到乙醇，在饮用证明中是有效的。另一方面，精神兴奋剂被称为继滥用之后的第三个术语，年轻人的滥用构成了一个问题。将甲基苯丙胺溶于乙醇中，然后以5 mg/kg的剂量腹腔注射甲基苯丙胺，以4g/kg的剂量经口给予乙醇，并同时给予甲基苯丙胺和乙醇，此次考虑对乙醇代谢和甲基苯丙胺代谢的影响。在给予乙醇、甲基苯丙胺、乙醇和甲基苯丙胺同时给药后，将大鼠从第1天至第7天置于20℃孵育箱中，并测量乙醇、乙基葡萄糖醛酸苷、甲基苯丙胺和代谢产物。 ...更多信息 给药组和甲基苯丙胺同时给药组在24小时后的血清和尿液中未检测到。乙醇和甲基苯丙胺同时给药后24小时，从血清和尿液中检测到乙基葡萄糖醛酸苷。该结果表明，乙基葡萄糖醛酸苷的测量在饮用证明中是有效的。甲基苯丙胺同时给药对肝、肾和脑中葡萄糖醛酸乙酯浓度无影响。同时给予乙醇对甲基苯丙胺的代谢也有影响。死后第7天，在肝脏、肾脏和脑组织中检测到乙醇的存在。死后第7天的乙醇含量与死后第1天相近。乙醇组和甲基苯丙胺同时给药组肝、肾、脑中葡萄糖醛酸乙酯浓度无差异。少