Hair Ethyl Glucuronide as a Long Term Alcohol Biomarker

头发乙基葡萄糖醛酸作为长期酒精生物标志物

• 批准号: 7154540
• 负责人: CHARLES A PLATE
• 金额: $ 10.76万
• 依托单位: U.S. DRUG TESTING LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7154540
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; biomarker; clinical research; diagnosis design /evaluation; diagnostic tests; drug /alcohol abstinence; glucuronides; hair; human subject; noninvasive diagnosis; substance abuse related behavior

DESCRIPTION (provided by applicant): There is a need for a highly sensitive (> 90%) and specific (> 90%) long term biomarker to both detect and monitor individuals who are heavy users of alcohol. Monitoring short term (3-5 days) alcohol use and abuse by impaired professionals by using urine ethyl glucuronide (EtG) has been shown to be both sensitive and specific (> 90%). Recently, evidence has emerged that EtG in hair may be able to detect long term abusers of alcohol with a sensitivity approaching 100%. With these results as background, this Phase I study will extract EtG from hair of patients admitted for residential treatment of alcohol use disorders at Rogers Memorial Hospital (RMH). The demographics of RMH's alcohol treatment program include impaired professionals and more than 40% of patients are women. The aim of this Phase I study is to determine whether EtG levels in hair can distinguish between heavy abusers of alcohol (n= 50) and non-drinking (n=50) with a sensitivity and specificity of greater than 90%. Using the statistical procedure of a receiver-operating characteristic (ROC) plot we will examine the whole spectrum of sensitivities and specificities over the entire range of hair EtG values obtained. We will also investigate the effects of long- term abstinence of the alcoholic patients on their hair EtG levels by analyzing hair samples taken from them after 45 days of residential treatment. In this study, feasibility of hair EtG as an alcohol long term abuse marker is defined as a test having a sensitivity and specificity of 90% or greater. If feasibility in this Phase I study is established, a Phase II study will expand to include women and pregnancy, binge and college drinking, transplant recipients and the development of a commercial hair EtG test. Alcohol abuse is an illness that has monumental consequences on people's every day lives, their physical and mental health, and the economies of nations. Treatment of an illness is dependent upon an early diagnosis and the current methods of self-reporting and the diagnostic tests for alcohol that are available do not detect most instances of alcohol abuse. The hair ethyl glucuronide test may prove to have superior sensitivity, specificity and ability to detect chronic alcohol abuse than the alcohol biomarkers currently in use, and be the first of a new generation of alcohol biomarkers that have a really significant impact on the treatment of this disease.

描述(由申请人提供)：需要一种高度敏感(90%)和特定(90%)的长期生物标志物来检测和监测酗酒者。使用尿乙基葡萄糖醛酸苷(EtG)监测受损专业人员的短期(3-5天)酒精使用和滥用已被证明既敏感又特异(&gt；90%)。最近，有证据表明，头发中的EtG可能能够检测到长期酗酒者，敏感度接近100%。以这些结果为背景，这项第一阶段的研究将从罗杰斯纪念医院(RMH)住院治疗酒精使用障碍的患者的头发中提取EtG。RMH酒精治疗计划的人口统计数据包括受损的专业人员，超过40%的患者是女性。这项第一阶段研究的目的是确定头发中的EtG水平是否可以区分重度酗酒者(n=50)和不饮酒者(n=50)，其敏感度和特异度超过90%。使用接收器工作特性(ROC)图的统计程序，我们将检查获得的毛发EtG值的整个范围内的整个灵敏度和特异度的整个频谱。我们还将通过对住院治疗45天后采集的头发样本进行分析，研究长期戒酒对他们头发EtG水平的影响。在这项研究中，头发EtG作为酒精长期滥用标记的可行性被定义为具有90%或更高的灵敏度和特异度的测试。如果这项第一阶段研究的可行性得到确立，第二阶段研究将扩大到包括妇女和怀孕、酗酒和大学饮酒、移植接受者以及开发商业毛发EtG测试。酗酒是一种对人们的日常生活、身心健康和国家经济产生巨大影响的疾病。疾病的治疗取决于早期诊断，目前的自我报告方法和现有的酒精诊断测试不能发现大多数酗酒情况。头发乙基葡萄糖醛酸脂测试可能被证明比目前使用的酒精生物标记物具有更高的敏感性、特异性和检测慢性酒精滥用的能力，并将成为对这种疾病的治疗产生真正重大影响的新一代酒精生物标记物中的第一个。

项目成果

Alcohol mixed with energy drinks: Are there associated negative consequences beyond hazardous drinking in college students?

• DOI: 10.1016/j.addbeh.2013.04.003
• 发表时间: 2013-09-01
• 期刊: ADDICTIVE BEHAVIORS
• 影响因子: 4.4
• 作者: Berger, Lisa;Fendrich, Michael;Fuhrmann, Daniel
• 通讯作者: Fuhrmann, Daniel

The utility of collateral student drinking reports: Evidence from a biomarker study.

附带学生饮酒报告的效用：来自生物标志物研究的证据。

• DOI: 10.1016/j.addbeh.2015.06.028
• 发表时间: 2015
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Fendrich,Michael;Fuhrmann,Daniel;Berger,Lisa;Plate,Charles;Lewis,Douglas;Jones,Joseph
• 通讯作者: Jones,Joseph

The association of long-term alcohol biomarkers with risk for alcohol-related injury: Implications for screening.

• DOI: 10.1080/14659891.2016.1217090
• 发表时间: 2017
• 期刊: Journal of substance use
• 影响因子: 0.8
• 作者: Fendrich M;Berger L;Fuhrmann D
• 通讯作者: Fuhrmann D