Effects of Kampo formulations on the olfactory bulb lesioned mice, acute anosmia model.
汉方制剂对嗅球损伤小鼠急性嗅觉丧失模型的影响。
基本信息
- 批准号:16590562
- 负责人:
- 金额:$ 1.73万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2005
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Reduction of olfactory sense is one of the symptoms of senile dementia of the Alzheimer type (SDAT). Some researchers hypothesize that changes in the olfactory system are not only a symptom but also a cause for SDAT, but little is known about the correlation between olfactory sense and memory.. In animal experiments, a reduction of memory maintenance has been reported in rats after olfactory bulbectomy. The role of the olfactory bulb in rodents is related to exchange of information, sex instinct and emotion caused by odor. The olfactory bulb is not only an organ of smell but is also related to emotional behavior. Spraying zinc sulfate into the nasal cavity promotes the secretion of glutamate, so that the sense of smell is definitely induced by obstruction of the regeneration of olfactory bulb epithelial cells. In the experiments until now, reductions of learning memory and of the neurotransmitters in the brain were observed to be induced by zinc sulfate.We investigated the effects of Kampo formulation, Kamishoyosan, on changes of neurotransmitters and reduction of learning memory in mice with olfactory bulb lesioned mice. Kamishoyosan extract was administered orally and an improvement in learning memory and reversal of the decrease of neurotransmitters in the brain were observed. It is therefore suggested that Kamishoyosan may improve learning memory repairing the injury to the neurons and restoring the amount of neurotransmitters.
嗅觉减退是阿尔茨海默型老年期痴呆(SDAT)的症状之一。一些研究人员假设,嗅觉系统的变化不仅是SDAT的症状,也是SDAT的原因,但对嗅觉和记忆之间的相关性知之甚少。在动物实验中,据报道,大鼠嗅球切除后记忆维持能力下降。在啮齿动物中,嗅球的作用与信息交换、性本能和气味引起的情感有关。嗅球不仅是嗅觉器官,还与情绪行为有关。鼻腔喷锌促进谷氨酸的分泌,因此嗅觉肯定是通过阻碍嗅球上皮细胞的再生而诱导的。在迄今为止的实验中,观察到了硫酸锌引起的学习记忆和脑内神经递质的减少。我们观察了Kampo制剂龟山散对嗅球损伤小鼠神经递质变化和学习记忆减少的影响。口服龟背山提取物后,可改善学习记忆,逆转脑内神经递质的下降。提示龟板散可改善学习记忆,修复神经元损伤,恢复神经递质的含量。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of Kamishoyosan on experimental memory deficit animal models
上正阳散对实验性记忆缺陷动物模型的影响
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Toriizuka K;Nishigaki Y;Hori Y;Fujii M;Fukumura M;Tsukada M;Hirai Y;Ida Y.
- 通讯作者:Ida Y.
数種の健忘モデル動物に対する加味逍遙散の影響
上正阳散对几种失忆症模型动物的影响
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:鳥居塚和生;西垣陽子;堀由美子;藤井幹雄;福村基徳;塚田愛;平井康昭;伊田喜光
- 通讯作者:伊田喜光
数種の健忘モデル動物に対する加味逍遥散の影響
上正阳散对几种失忆症模型动物的影响
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:鳥居塚和生;西垣陽子;堀由美子;藤井幹雄;福村基徳;塚田愛;平井康昭;伊田喜光
- 通讯作者:伊田喜光
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IDA Yoshiteru其他文献
IDA Yoshiteru的其他文献
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{{ truncateString('IDA Yoshiteru', 18)}}的其他基金
Comparative Studies of Medicinal Herbs listed in Pharmacopoeia in the East Asia
东亚药典所收药草的比较研究
- 批准号:
13672229 - 财政年份:2001
- 资助金额:
$ 1.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on the constitutes of Achyranthes fauriei having the 100 times higher activity on adhesion of PMNs to LPS-treated HUVECs than Sialyl Lewis X
牛膝的组成研究,其对 PMN 与 LPS 处理的 HUVEC 的粘附活性比 Sialyl Lewis X 高 100 倍
- 批准号:
10671997 - 财政年份:1998
- 资助金额:
$ 1.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
STUDIES FOR THE ESTIMATION PROCEDURE ON THE QUALITY OF ALISMATIS RHIZOMA
泽泻品质评价方法的研究
- 批准号:
61571016 - 财政年份:1986
- 资助金额:
$ 1.73万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
Studies of active substances and action mechanisms of traditional Japanese medicines on anosmia, olfactory disturbance, using olfactory bulb lesioned mice.
使用嗅球受损小鼠研究日本传统药物对嗅觉丧失、嗅觉障碍的活性物质和作用机制。
- 批准号:
21590776 - 财政年份:2009
- 资助金额:
$ 1.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)