To clarify the mechanism of Th1 suppression to protect renal function by angiotensin II receptor blocker

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The change of Th1/Th2 balance is critical for the development of renal damage in various kind of chronic nephritis. Predominant Th1 activity is often seen in the patients and model mice with active stage of systemic lupus erythematosus (SLE). We gave angiotensin type II receptor blocker, olmesartan, 10mg/kg/day to MRL/lps (spontaneously manifesting lupus) mice (n = 10) aged 9 weeks for 19 weeks. Then, we checked Interferon-γ (INF-γ) and interleukin-4 (IL-4) levels in the supernatant of the cultured T cells from the spleen in mice MRL/lps mice with or without olmesartan administration. This revealed that there was no difference in INF-γ and IL-4 levels in the supernatants between the two groups. However, MRL/lps mice to which olmesartan was administered lived longer, than the MRL/lps mice to which olmesartan was not administered. Although olmesartan do not suppress the Th1 activity in MRL/lps mice, it may have a beneficial effect on various organs such as heart. This beneficial effect may elongate the life span of MRL/lps mice.