To clarify the mechanism of Th1 suppression to protect renal function by angiotensin II receptor blocker

阐明血管紧张素II受体阻滞剂抑制Th1保护肾功能的机制

• 批准号: 16591010
• 负责人: IGARASHI Takashi
• 金额: $ 2.24万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591010/
• 关键词: angiotensin type II receptor blocker; Th1 action; renoprotective medicine; アンギオテンシンII受容体拮抗薬; アンギオテンシンII受容体; ARB; 腎機能

The change of Th1/Th2 balance is critical for the development of renal damage in various kind of chronic nephritis. Predominant Th1 activity is often seen in the patients and model mice with active stage of systemic lupus erythematosus (SLE). We gave angiotensin type II receptor blocker, olmesartan, 10mg/kg/day to MRL/lps (spontaneously manifesting lupus) mice (n = 10) aged 9 weeks for 19 weeks. Then, we checked Interferon-γ (INF-γ) and interleukin-4 (IL-4) levels in the supernatant of the cultured T cells from the spleen in mice MRL/lps mice with or without olmesartan administration. This revealed that there was no difference in INF-γ and IL-4 levels in the supernatants between the two groups. However, MRL/lps mice to which olmesartan was administered lived longer, than the MRL/lps mice to which olmesartan was not administered. Although olmesartan do not suppress the Th1 activity in MRL/lps mice, it may have a beneficial effect on various organs such as heart. This beneficial effect may elongate the life span of MRL/lps mice.

Th 1/Th 2平衡的改变在各种慢性肾炎肾损害的发生、发展中起重要作用。系统性红斑狼疮（SLE）活动期患者和模型小鼠Th 1细胞活性均占优势。我们给9周龄的MRL/lps（自发性狼疮）小鼠（n = 10）给予血管紧张素II型受体阻断剂奥美沙坦10 mg/kg/天，共19周。然后，我们检测了在给予或不给予奥美沙坦的情况下，MRL/lps小鼠脾脏中培养的T细胞上清液中的干扰素-γ（INF-γ）和白细胞介素-4（IL-4）水平。这表明两组之间上清液中INF-γ和IL-4水平无差异。然而，给予奥美沙坦的MRL/lps小鼠的寿命长于未给予奥美沙坦的MRL/lps小鼠。虽然奥美沙坦不抑制MRL/lps小鼠的Th 1活性，但它可能对心脏等多种器官具有有益作用。这种有益的作用可以延长MRL/lps小鼠的寿命。

项目成果

Mutational analysis of idiopathic renal hypouricemia in Korea

• DOI: 10.1007/s00467-005-1863-3
• 发表时间: 2005-07-01
• 期刊: PEDIATRIC NEPHROLOGY
• 影响因子: 3
• 作者: Cheong, HI;Kang, JH;Choi, Y
• 通讯作者: Choi, Y

Comparative ontogeny, processing and segmental distribution of the renal chloride channel, CIC-5.

肾氯离子通道 CIC-5 的比较个体发育、加工和节段分布。

• 发表时间: 2004
• 期刊: Kidney Int 65(1)
• 作者: Jouret F;Igarashi T;et al.
• 通讯作者: et al.

Molecular and clinical studies of Dent's disease in Japan : biochemical examination and renal ultrasonography do not predict carrier state.

日本登特氏病的分子和临床研究：生化检查和肾脏超声检查不能预测携带者状态。

• 发表时间: 2004
• 期刊: Clin Nephrol. 61(4)
• 作者: Matsuyama T;Awazu M;Oikawa T;Inatomi J;Sekine T;Igarashi T.
• 通讯作者: Igarashi T.

Functional characterization of LMX1B mutations associated with nail-patella syndrome

• DOI: 10.1203/01.pdr.0000157674.63621.2c
• 发表时间: 2005-06-01
• 期刊: PEDIATRIC RESEARCH
• 影响因子: 3.6
• 作者: Sato, U;Kitanaka, S;Igarashi, T
• 通讯作者: Igarashi, T

Exercise induced acute renal failure associated with renal hypouricemia : results of a questionnaire-based survey in Japan.

运动诱发的急性肾功能衰竭与肾性低尿酸血症相关：日本一项基于问卷调查的结果。

• 发表时间: 2005
• 期刊: Nephrol Dial Transplant 19・4
• 作者: Ohta T;Sakano T;Igarashi T;et al.
• 通讯作者: et al.