Establishment of predictive Assay for radiosensity of tumors

肿瘤放射敏感性预测分析方法的建立

• 批准号: 16591883
• 负责人: YOSHINO Norio
• 金额: $ 2.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591883/
• 关键词: MRI; Tumor; Glucose metabolism; Fluorine; 放射線治療

On the occasion of radiation treatment of the malignant tumor, if radiosensitivity of the neoplasm can be estimated before the treatment begining, the fractionation-of-irradiation which the accelerated irradiation, the hyperfractionate irradiation and so on are appropriate to become able to be more rational chosen, being adaptable and the improvement of the treatment results can look forward to it. If the MRI can evaluate radiosensitivity of the neoplasm, the radiation-response of the neoplasm can be esimated with non-invasiveness.In this research, it paid attention to fluoric nucleus (19F). The evaluation of the cell function will become possible with 19F in vivo imageIt examined the optimization of the pulse sequences such as the spin echo, the gradient echo with 19F coil. In any order, the signal-strength of 19F was low extremely and didn't result in the optimization. In any order, the signal-strength was low extremely and didn't result in the optimization of the order. The research could not be released.

在恶性肿瘤放射治疗时，如果在治疗开始前能够估计肿瘤的放射敏感性，加速照射、超分割照射等适宜的分割照射方式就能够更加合理地选择，具有适应性，治疗效果的提高是可以期待的。如果MRI能够评估肿瘤的放射敏感性，就可以无创地评估肿瘤的放射反应。本研究重点关注氟核（19F）。利用 19F 体内图像可以对细胞功能进行评估。它检查了 19F 线圈的自旋回波、梯度回波等脉冲序列的优化。无论哪种顺序，19F的信号强度都极低，没有达到优化的目的。无论哪种顺序，信号强度都极低，没有导致顺序的优化。该研究无法发布。