Reduction of parotid damage by Continuous Hyperfractionated Accelerated Radiotherapy

连续超分割加速放射治疗减少腮腺损伤

• 批准号: 09671917
• 负责人: YOSHINO Norio
• 金额: $ 1.98万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671917/
• 关键词: CHART; MTC; radiation damage; parotid gland; 磁気共鳴撮像法; 磁化移動; フッ素; アミラーゼ

The parotid damage with Continuous Hyperfractionated Accelerated Radiotherapy (CHART) was examined by the model experiment system. To detect the parotid damage, Magnetization Transfer Contrast (MTC) was made an image with MRI device. To evaluate the damage of the parotid gland, X rays were irradiated to the rat parotid gland with 5Gy to 30Gy. We measured the serum and the urine amylase activity of the damaged parotid origin, and in the parotid at the time of the remaining total amylase passing.As for pulse sequence used to detect MTC, it has been understood that gradient echo or FISP is useful. It was clarified to the maximum value appearance of the urine amylase activity that time was different by the difference of the absorbed dose of the parotid. It is suggested that the mechanism of the appearance of the cell death by the irradiation of the parotid acinar cell is different depending on the dose.

应用模型实验系统研究了连续超分割加速放射治疗（CHART）对腮腺的损伤。用磁共振成像仪对腮腺进行磁化传递对比成像，以检测腮腺的损伤情况.用5 ~ 30 Gy的X线照射大鼠腮腺，观察腮腺的损伤情况。我们测量了受损腮腺起源的血清和尿淀粉酶活性，以及剩余总淀粉酶通过时腮腺中的淀粉酶活性。至于用于检测MTC的脉冲序列，已经理解梯度回波或FISP是有用的。说明尿淀粉酶活性最大值出现的时间因腮腺吸收剂量的不同而不同。这表明，腮腺腺泡细胞的照射的细胞死亡的外观的机制是不同的剂量依赖。