Fabrication of self-setting foam for bone graft material

骨移植材料自凝泡沫的制备

• 批准号: 16591957
• 负责人: UDOH Koh-ichi
• 金额: $ 2.43万
• 依托单位: Yamaguchi University (2005)Kyushu University (2004)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591957/
• 关键词: Bone substitute naterial; apatite; hydroxy apatite; self-setting; 3D interconnected pores; 炭酸アパタイト

Calcium phosphate faom is exerent for bone graft material. Various methods are applicable for the fabrication of porous HAP foam. Among these method, only the foam method is known to permit three-dimensional fully interconnected porous structure similar to cancellous bone. But, it is very difficult to make this foam same as a shape of bone defect using foam method. Small size foam hardened each other after filling to the defect clear this problem. We tried to develop the self setting foam using small size particle of α-TCP foam. This α-TCP foam hardened with NaH_2PO_4 solution or distilled water. Setting time was about 5 hours at room temperature with NaH_2PO_4 solution, and 24hours at 200℃ with distilled water. Chemical product after setting was DCPD with NaH_2PO_4 solution, and HAP with distilled water. After setting, needle like crystals which length was about 20 to 50 μm were formed on the surface of α-TCP foam. Needle like crystals penetrated each other during the setting reaction. This contributed to set in the same mechanism as dental plaster.

磷酸钙是骨移植材料中不可缺少的。各种方法可用于制造多孔HAP泡沫。在这些方法中，已知只有泡沫方法允许类似于松质骨的三维完全互连的多孔结构。但是，使用泡沫方法很难使这种泡沫与骨缺损的形状相同。小尺寸泡沫硬化后互相填充，以消除缺陷.我们尝试用小粒径的α-TCP泡沫研制自凝泡沫。这种α-TCP泡沫用NaH_2PO_4溶液或蒸馏水硬化。在室温下用NaH_2PO_4溶液凝结时间约为5小时，在200℃下用蒸馏水凝结时间约为24小时。固化后的化学产品为DCPD与NaH_2PO_4溶液，HAP与蒸馏水。凝固后，α-TCP泡沫表面形成长约20 ~ 50 μm的针状晶体。针状晶体在凝固反应过程中相互渗透。这有助于与牙科石膏相同的机制。

项目成果

The effect of Pt and Pd alloying additions on the corrosion behavior of titanium in fluoride-containing environments

• DOI: 10.1016/j.biomaterials.2004.07.022
• 发表时间: 2005-05-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Nakagawa, M;Matono, Y;Ishikawa, K
• 通讯作者: Ishikawa, K

Fabrication of Hydroxyapatite Block from Gypsum Block Based on (NH_4)_2HP0_4 Treatment

基于(NH_4)_2HP0_4处理的石膏块制备羟基磷灰石块

• 发表时间: 2005
• 期刊: Dental Materials Journal 24・4
• 作者: Munar M;Udoh K;Ishikawa K;Matsuya S;Nakagawa M;村田比呂司;Y.Suzuki
• 通讯作者: Y.Suzuki

Hardening of calcium hydroxide compact by carbonization.

通过碳化使氢氧化钙压块硬化。

• 发表时间: 2004
• 期刊: Journal of the Ceramic Society of Japan 112
• 作者: Yumiko Suzuki;Shigeki Matsuya;Koh-ichi Udoh;Masaharu Nakagawa;Yoshihiro Tsukiyama;Kiyoshi Koyano;Kunio Ishikawa;K.Ishikawa et al.
• 通讯作者: K.Ishikawa et al.

Fabrication of biphasic calcium phasphate foam

双相磷酸钙泡沫的制备

• 发表时间: 2005
• 期刊: Arehives of BioCeramics Research 5
• 作者: Matono Y;Nakagawa M 他;Minakuchi H;Hong G;K.Udoh
• 通讯作者: K.Udoh

Preparation of carbonate apatite (CHA) foam by hydrothermal treatment of α-TCP foam in ammonium carbonate solutions

碳酸铵溶液中水热处理α-TCP泡沫制备碳酸磷灰石(CHA)泡沫

• 发表时间: 2004
• 期刊: Archives of BioCeramics Research 4
• 作者: 水口 一;前川賢治;窪木拓男;GT Clark.;Kunio Ishikawa;Hong G;Nakagawa M 他;Minakuchi H et al.;Koh-ichi Udoh
• 通讯作者: Koh-ichi Udoh