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Does the prosthodontic treatment for anodontia cause the neuroplastic change of cerebral cortex activity?

无牙修复治疗是否会引起大脑皮层活动的神经塑性改变？

基本信息

批准号：
16591969
负责人：
NARITA Noriyuki
金额：
$ 2.11万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

From the aspects of neural activation of cerebral cortex accompanying mastication and swallowing, the effects of partial prosthodontic treatment was investigated with NIRS system (Hitachi, ETG 100) and following results were obtained ;1. Using the principal component analysis for brain blood volume, muscle blood could be excluded from NIRS data, Hb mapping and topography were reconstructed with the changing of cerebral blood flow. Activation in the primary sensorimotor and post-parietal and supplementary motor cortices were indicated accompanying with the performance of matication and swallowing.2. Cortical activation of primary sensorimotor cortex, and post-parietal and supplementary motor cortex during mastication were decreased by the injection of anesthesia into infra-alveolar nerve, therefore oral sensation can affect to the cortical sensorimotor function and sensory integration.3. Masticatory loading and masticatory imagery activated the prefrontal cortex, and the focus of its activation was indicted in the bilateral dorsolateral prefrontal cortex areas.4. Cortical activation of prefrontal cortex during mastication was decreased by the injection of anesthesia into infra-alveolar nerve, therefore prefrontal cortex is involved in perception of oral sensory and sensorimotor integration.5. Oral dysesthesia indicated the hypofrontality in the prefrontal cortex comparing with healthy controls, it is therefore assumed that hypofrontality in mastication may reflect to the oral dysesthesia.6. Concerning the effects of prosthodontic treatment to the cortical activation, wearing partial denture more activated the sensorimotor and prefrontal cortices during mastication.It was assumed that the prosthodontic reconstruction of oral apparatus affects to the functional upgrading in the perception of oral sensory, the sensorimotor integration, and the masticatory motor planning and execution.

利用NIRS系统（Hitachi，ETG 100）从咀嚼和吞咽时大脑皮层神经激活的角度研究部分修复治疗的效果，得到以下结果： 1．利用脑血量的主成分分析，可以从NIRS数据中排除肌肉血，随着脑血流量的变化重建Hb图谱和地形图。初级感觉运动皮质、后顶叶运动皮质和辅助运动皮质的激活伴随着促动和吞咽的表现。2．牙槽下神经注射麻醉后，咀嚼过程中初级感觉运动皮层、后顶叶和辅助运动皮层的皮质激活减少，因此口腔感觉会影响皮质感觉运动功能和感觉统合。 3．咀嚼负荷和咀嚼意象激活前额叶皮层，其激活焦点位于双侧背外侧前额叶皮层区域。4．牙槽下神经注射麻醉后，咀嚼过程中前额皮质的激活减少，因此前额皮质参与口腔感觉和感觉运动整合的感知。 5．口腔感觉迟钝表明与健康对照者相比，前额叶皮层的额叶功能低下，因此推测咀嚼时的额叶功能低下可能反映了口腔感觉迟钝。6．就修复治疗对皮质激活的影响而言，佩戴局部义齿更能激活咀嚼过程中的感觉运动皮质和前额叶皮质。推测口腔修复重建影响口腔感觉知觉、感觉运动整合以及咀嚼运动规划和执行的功能升级。