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RE MOUTH ACTIVITIES INVOLVED IN THE PROCESS OF COGNITIVE DISORDERS?-IN SEARCH OF NEUROPATHOLOGIC ASSOCIATIONS-

RE 口腔活动参与认知障碍的过程？-寻找神经病理学关联-

基本信息

批准号：
21592473
负责人：
NARITA Noriyuki
金额：
$ 2.25万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Denture wearing is considered to improve chewing ability, chewing comfort, and quality of life(QOL) in elderly individuals. In order to clarify the effects of denture treatment on activation of the prefrontal cortex, which is involved in higher cognitive functions, we investigated the efficacy of wearing a denture prosthesis from the aspects of cognitive and jaw functions, and related prefrontal cortex activity. Partially edentulous patients were enlisted as subjects. Functional near infrared spectroscopy(f-NIRS) was used to detect changes of cerebral blood flow in the prefrontal cortex area, while cognitive functions were examined using questionnaires(SF36 v2, OHIP-J, and MMSE : Mini-mental state examination), with jaw muscle EMG and motions activities simultaneously investigated. Masticatory scores were also used to evaluate subjective awareness and consciousness of chewing ability. Statistical comparisons were performed between data obtained while wearing and not wearing a denture prosthesis. Significant increases were seen in chewing-related jaw functions, including jaw motion, jaw muscle EMG, and prefrontal cortex activity, while masticatory scores were also significantly improved by wearing a partial denture prosthesis as compared with the non-wearing condition. Prefrontal cortex activity caused by a wearing denture prosthesis was significantly related to masticatory score and masticatory EMG activities. During the process of denture treatment, the scores of dental and physical QOL, and MMSE showed improving trends as compared to the pre-therapeutic conditions. Based on our findings, we consider that dental treatment with a denture prosthesis may help to improve not only masticatory jaw functions, but also cognitive ability, as shown by prefrontal cortex activation and cognitive scores for oral and physical QOL.

佩戴义齿被认为可以改善老年人的咀嚼能力、咀嚼舒适度和生活质量。为了明确义齿治疗对参与高级认知功能的前额叶皮质激活的影响，我们从认知功能和颌功能以及相关的前额叶皮质活动方面研究了佩戴义齿修复体的效果。部分缺牙患者被纳入研究对象。采用功能近红外光谱（f-NIRS）检测前额叶皮质区脑血流量变化，采用问卷（SF36 v2、o髋关节- j、MMSE: Mini-mental state examination）检测认知功能，同时观察下颌肌电图和运动活动。咀嚼评分也用于评价咀嚼能力的主观意识和意识。对佩戴和不佩戴义齿时获得的数据进行统计比较。在咀嚼相关的下颌功能方面，包括下颌运动、下颌肌肌电图和前额叶皮层活动显著增加，而与不佩戴假牙的情况相比，佩戴部分假牙的咀嚼评分也显著提高。佩戴义齿后的前额叶皮层活动与咀嚼评分和咀嚼肌电图活动显著相关。在义齿治疗过程中，口腔生活质量和身体生活质量评分以及MMSE评分均较治疗前有改善趋势。基于我们的研究结果，我们认为假牙治疗不仅有助于改善咀嚼颌功能，还可以改善认知能力，这可以通过前额叶皮层激活和口腔和身体生活质量的认知评分来证明。