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Elucidation of temporomandibular disorders using contrast-enhancement MRI and analysis of synovial fluid/tissue

使用对比增强 MRI 和滑液/组织分析阐明颞下颌疾病

基本信息

批准号：
16591981
负责人：
FUKUDA Masayuki
金额：
$ 2.24万
依托单位：
Akita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591981/
关键词：
temporomandibular joint disorders MRI contrast-enhancement synovial tissue synovial fluid immunohistochemistry

项目摘要

The purpose of the pilot study was to elucidate the association between changes in gadopentetate dimeglumine (Gd-DTPA) contrast-enhancement of the temporomandibular joint (TMJ) space in MR image and clinical outcomes before and after treatment in patients with temporomandibular disorders (TMD). Gd-DTPA enhanced T1-weighted MR images with fat suppression were taken in ten patients with twelve painful TMJs before and after treatment. One patient was treated with splint therapy, eight with pumping manipuration, and one with arthroscopic surgery. Clinical findings were assessed on the basis of the mouth opening and joint pain level on visual analog scale (VAS) before and after treatment (Ohnuki T, Fukuda M, et al. : Magnetic resonance evaluation of the disk before and after arthroscopic surgery for temporomandibular joint disorders. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 96(2) : 141-148, 2003). After treatment, the mouth opening and joint pain level on VAS improved in all patients. The number of the enhanced joint spaces decreased from nine to three out of twelve TMJs after treatment. These results indicate that the contrast-enhancement in the joint space may be an index to improvement of clinical findings (particularly joint pain) after treatment. Level of the inflammatory mediators in synovial fluid of the TMD patients was higher than that of physically unimpaired persons. Therefore contrast-enhanced MRI may show inflammatory reaction of the TMJs. And most of TMD patients with high signal intensity in the mandibular condyle and/or the retrodiscal tissue in contrast-enhanced MRI have anterior disc displacement without reduction. In conclusion, high signal intensity of contrast-enhanced MRI might indicate the clinical stage of TMD.

本初步研究的目的是阐明颞下颌关节紊乱（TMD）患者MR图像中加多巴胺二聚乙二醇（Gd-DTPA）增强成像的变化与治疗前后临床结果的关系。采用Gd-DTPA增强t1加权MR对10例治疗前后12例疼痛性TMJs患者进行脂肪抑制。1例患者采用夹板治疗，8例采用抽吸手法，1例采用关节镜手术。根据治疗前后口腔开口和关节疼痛视觉模拟量表（VAS）评估临床表现（Ohnuki T, Fukuda M, et al.：关节镜手术治疗颞下颌关节疾病前后椎间盘磁共振评价）。口腔外科、口腔医学、口腔病理、口腔放射学、牙髓学(2):141-148,2003)。治疗后，所有患者在VAS上的开口和关节疼痛程度均有所改善。治疗后，12个tmj中强化关节间隙的数量从9个减少到3个。这些结果表明，关节间隙的对比增强可能是治疗后临床表现（特别是关节疼痛）改善的一个指标。TMD患者滑液中炎症介质的水平高于身体健全者。因此，增强MRI可显示颞下颌关节的炎症反应。而MRI造影显示在下颌髁突和/或椎间盘后组织有高信号强度的TMD患者，多数有前盘移位而无复位。综上所述，MRI增强高信号可提示TMD的临床分期。

项目成果

期刊论文数量（36）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of the position, mobility, and morphology of the disc by MRI before and after four different treatments for temporomandibular joint disorders

DOI：
10.1259/dmfr/25020275
发表时间：
2006-03-01
期刊：
DENTOMAXILLOFACIAL RADIOLOGY
影响因子：
3.3
作者：
Ohnuki, T;Fukuda, M;Miyamoto, Y
通讯作者：
Miyamoto, Y

A psychological study on patients with masticatory muscle disorder and sleep bruxism.

咀嚼肌障碍和睡眠磨牙症患者的心理研究。

DOI：
发表时间：
2006
期刊：
The Joumal of Craniomandibular Practice 24・3
影响因子：
0
作者：
Takemura T;Takahashi T;Fukuda M;Ohnuki T;Asanuma T;Masuda Y;Kondoh H;Konbo H;Kanbayashi T;Shimizu
通讯作者：
Shimizu

Isolation and characterization of synovial cells from the human temporomandibular joint