Elucidation of temporomandibular disorders using contrast-enhancement MRI and analysis of synovial fluid/tissue

使用对比增强 MRI 和滑液/组织分析阐明颞下颌疾病

基本信息

批准号：
16591981
负责人：
FUKUDA Masayuki
金额：
$ 2.24万
依托单位：
Akita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591981/
关键词：
temporomandibular joint disorders MRI contrast-enhancement synovial tissue synovial fluid immunohistochemistry

项目摘要

The purpose of the pilot study was to elucidate the association between changes in gadopentetate dimeglumine (Gd-DTPA) contrast-enhancement of the temporomandibular joint (TMJ) space in MR image and clinical outcomes before and after treatment in patients with temporomandibular disorders (TMD). Gd-DTPA enhanced T1-weighted MR images with fat suppression were taken in ten patients with twelve painful TMJs before and after treatment. One patient was treated with splint therapy, eight with pumping manipuration, and one with arthroscopic surgery. Clinical findings were assessed on the basis of the mouth opening and joint pain level on visual analog scale (VAS) before and after treatment (Ohnuki T, Fukuda M, et al. : Magnetic resonance evaluation of the disk before and after arthroscopic surgery for temporomandibular joint disorders. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 96(2) : 141-148, 2003). After treatment, the mouth opening and joint pain level on VAS improved in all patients. The number of the enhanced joint spaces decreased from nine to three out of twelve TMJs after treatment. These results indicate that the contrast-enhancement in the joint space may be an index to improvement of clinical findings (particularly joint pain) after treatment. Level of the inflammatory mediators in synovial fluid of the TMD patients was higher than that of physically unimpaired persons. Therefore contrast-enhanced MRI may show inflammatory reaction of the TMJs. And most of TMD patients with high signal intensity in the mandibular condyle and/or the retrodiscal tissue in contrast-enhanced MRI have anterior disc displacement without reduction. In conclusion, high signal intensity of contrast-enhanced MRI might indicate the clinical stage of TMD.

试点研究的目的是阐明MR图像中颞下颌关节（TMJ）空间中摄影剂（GD-DTPA）对比增强的变化与颞细胞疾病（TMD）患者治疗前后的临床结果（TMJ）的对比增强。在治疗前后，在十二例疼痛的TMJ患者中拍摄了GD-DTPA增强的T1加权MR图像，并抑制了脂肪。一名患者接受夹板疗法治疗，八名泵送操作，另一名接受关节镜手术。根据治疗前后的视觉模拟量表（VAS）对临床发现进行评估（Ohnuki T，Fukuda M等：关节脂肪颌骨前后和关节脂肪症之前和之后的磁盘的磁共振评估评估次颌骨手术关节疾病。治疗后，所有患者的口腔口张开和关节疼痛水平都得到了改善。治疗后，增强的关节空间的数量从十二个TMJ中的九个减少到三个。这些结果表明，关节空间中的对比增强可能是治疗后改善临床发现（尤其是关节疼痛）的指数。 TMD患者滑液中炎症介质的水平高于身体不受影响的人。因此，对比增强的MRI可能显示TMJ的炎症反应。大多数TMD患者在下颌con和/或对比增强的MRI中具有高信号强度的高信号强度的患者具有前盘位移而不会减少。总之，对比度增强的MRI的高信号强度可能表明TMD的临床阶段。

项目成果

期刊论文数量（36）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of the position, mobility, and morphology of the disc by MRI before and after four different treatments for temporomandibular joint disorders

DOI：
10.1259/dmfr/25020275
发表时间：
2006-03-01
期刊：
DENTOMAXILLOFACIAL RADIOLOGY
影响因子：
3.3
作者：
Ohnuki, T;Fukuda, M;Miyamoto, Y
通讯作者：
Miyamoto, Y

Isolation and characterization of synovial cells from the human temporomandibular joint

DOI：
10.1111/j.1600-0714.2006.00369.x
发表时间：
2006-02-01
期刊：
JOURNAL OF ORAL PATHOLOGY & MEDICINE
影响因子：
3.3
作者：
Nagai, H;Miyamoto, Y;Fukuda, M
通讯作者：
Fukuda, M

A psychological study on patients with masticatory muscle disorder and sleep bruxism.

咀嚼肌障碍和睡眠磨牙症患者的心理研究。

DOI：
发表时间：
2006
期刊：
The Joumal of Craniomandibular Practice 24・3
影响因子：
0
作者：
Takemura T;Takahashi T;Fukuda M;Ohnuki T;Asanuma T;Masuda Y;Kondoh H;Konbo H;Kanbayashi T;Shimizu
通讯作者：
Shimizu

A psychological study on patients with masticatory muscle disorder and sleep bruxism

咀嚼肌障碍与睡眠磨牙症患者的心理研究