Research on the suitable directions for use of Enamel Matrix Derivatives used for tooth transplantation and replantation.

牙移植再植牙釉质基质衍生物的适宜使用方向研究。

基本信息

批准号：
16591982
负责人：
HAMAMOTO Yoshioki
金额：
$ 2.05万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

Animal experimentThe effect of EMD to the periodontal regeneration of the transplanted teeth with periodontal obstacles was clarified using the experiment system which transplants a rat molar to abdomen subcutaneous tissue. EMD was able to guide periodontal regeneration of the teeth with the obstacle by 30 minute-dryness at room temperature. However, the regeneration was hardly observed on the portion with necrotic tissues. In the case where a periodontal membrane is removed mechanically, the resorption of dental root and the bone formation on the root surface were observed. When the obstacle of the periodontal membrane was carried out broadly and seriously, the effect of EMD was not perfect and the periodontal membrane was not completely reproducible.The experiment which verifies the production of enamel matrix by odontogenic tumor cells was conducted. The local administration of the MNU (methyl nitrosourea) was carried out at the rat mandibles. The enamel matrix secretion by the norm … More al enamel-epithelium cells and that of the tumor cells were compared. The several kinds of enamel-epithelium cells, such as the ameloblasts, the Hertwig's root sheath cells, and the Malassez's epithelial rests cells in rat mandibles proliferated and were induced into the odontogenic tumors. The productivities of enamel matrix by the tumor cells reflected those of the origin cells. The useful view was acquired by this research on the origin of odontogenic tumors. Clinical study.Examination of the usage of EMD to the periodontal regeneration after tooth transplantation. The tooth with the root exposed by teeth extrusion was used as a transplant tooth. EMD guided the periodontal regeneration on the exposure root surface. The effect was clinically confirmed by the improvement of probing attachment level and pocket depth in two cases.The purpose of an operation, a background, and conditions of patients differs between the replantation of an avulsed tooth and the tooth transplantation. In the former case, the tooth luxation was happened accidentally and local and systemic conditions differed in cases. In the latter case, a schedule operation was performed under the almost uniform and good conditions. Clinical research which clarifies the factor which affects the prognosis after a transplant and replantation of a dislocation tooth was done by comparing the preoperative conditions and postoperative courses. Less

动物实验EMD对使用牙周障碍物移植牙齿的牙周再生的作用使用实验系统阐明，该实验系统将大鼠磨牙移植到腹部皮下组织。 EMD能够在室温下以30分钟的障碍物指导牙齿的牙周再生。然而，在与坏死组织的部分几乎没有观察到再生。在机械去除牙周膜的情况下，观察到牙根的解析和根表面上的骨形成。当牙周膜的障碍物被广泛而认真地进行时，EMD的作用并不完美，牙周膜的作用也不完全可重现。进行了牙源性肿瘤细胞验证牙釉质基质的实验。 MNU的局部给药（硝酸甲基）是在大鼠下颌骨上进行的。比较了标准的搪瓷基质分泌……比较了更多的Al搪瓷细胞和肿瘤细胞的细胞。几种类型的搪瓷 - ePitelium细胞，例如成成布，赫特维格的根鞘细胞，以及马拉西斯的上皮细胞在大鼠下颌骨中休息的细胞增殖，并诱导到牙源性肿瘤中。肿瘤细胞的搪瓷基质产物反映了原始细胞的产物。这项研究对牙源性肿瘤的起源获得了有用的观点。临床研究。在牙齿移植后将EMD使用对牙周再生。用牙齿伸出的牙齿被用作移植牙齿。 EMD指导了暴露根表面上的牙周再生。在两种情况下，通过探测附着水平和口袋深度的改善来证实效果。手术，背景和患者条件的目的在撕裂牙齿的补充与牙齿移植之间有所不同。在前一种情况下，牙齿奢侈发生在偶然的情况下，局部和系统条件在情况下有所不同。在后来的情况下，在几乎均匀且良好的条件下进行了计划操作。通过比较术前条件和术后课程，完成了影响移植后预后和脱位牙齿后预后的因素的临床研究。较少的