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Development of Cancer Ablation System using the High-frequency Inductive Heating of Ferrite Powder

利用铁氧体粉末高频感应加热开发癌症消融系统

基本信息

批准号：
17500332
负责人：
NAOHARA Takashi
金额：
$ 2.3万
依托单位：
Ehime University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

An attempt has been made to develop a cancer ablation therapy applying the high-frequency inductive heating of the ferrite powder, as a cooperative approach from medical, physical and engineering fields. The Mg ferrite powder was prepared by the reverse coprecipitation method using metal nitrates as the starting materials. In the instillation of the ferrite powder into a tumor, it is indispensable to obtain a magnetic fluid consists of nano-scale particles. Thus, we investigated the dispersion ability of the magnetite powder prepared by the reverse coprecipitation method. Controlling their pH value by the addition of hydrochloric acid, a significant improvement of dispersion ability was achieved in the range from pH1 to pH3.The heating properties of both the needle-shaped Mg ferrite obtained using a sintering technique and the Mg ferrite powder packed into the Ti tube were measured in the magnetic field of 1.77kA/m at 370kHz. The increase in temperature (ΔT) reached 16 ℃ for the former inserted in the cylindrical clay. The ΔT value of three complementary Mg ferrite sticks was as high as 40℃ at the central position, suggesting that the heating ability of these magnetic materials is sufficient for the ablation of liver tumor. Although the Ti tube without the Mg ferrite powder or Ti rod exhibited poor heat generation ability, the ΔT of the latter was markedly improved by the existence of Mg ferrite powder in the Ti tube. The apparatus for the high-frequency inductive ablation of liver cancer was produced on trial for the clinical testing on patients. The experiments on rats and rabbits allowed us to conclude that the usage of the Mg ferrite powder to the thermal coagulation therapy is effective owing to the large heat generation ability in the high-frequency magnetic fields.

作为医学、物理和工程领域的合作方法，已经尝试开发应用铁氧体粉末的高频感应加热的癌症消融治疗。以金属硝酸盐为原料，采用反相共沉淀法制备了镁铁氧体粉体。在将铁氧体粉末滴注到肿瘤中时，获得由纳米级颗粒组成的磁流体是必不可少的。因此，我们研究了通过反向共沉淀法制备的磁铁矿粉末的分散能力。在pH = 1 ~ 3的范围内，通过加入盐酸来控制其pH值，可显著提高镁铁氧体的分散能力。在1.77kA/m、370 kHz的磁场中，对烧结法制备的针状镁铁氧体和填充在钛管中的镁铁氧体粉末的热性能进行了测试。前者插入圆柱形粘土中的温升（ΔT）达到16 ℃。三个互补的镁铁氧体棒的ΔT值在中心位置高达40℃，表明这些磁性材料的加热能力足以用于肝肿瘤的消融。虽然不含镁铁氧体粉末或钛棒的钛管表现出较差的发热能力，但在钛管中存在镁铁氧体粉末后，后者的ΔT显著提高。研制了肝癌高频消融治疗仪，并进行了临床试验。通过对大鼠和家兔的实验，我们可以得出结论，由于在高频磁场中具有较大的发热能力，因此将镁铁氧体粉末用于热凝固治疗是有效的。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

癌の高周波誘導焼灼法に用いる針状フェライトの開発

开发用于癌症射频感应消融的针状铁氧体

DOI：
发表时间：
2006
期刊：
工学ジャーナル(愛媛大学理工学研究科紀要) 5
影响因子：
0
作者：
猶原隆他
通讯作者：
猶原隆他

Development of the High-Frequency Inductive Ablation Therapy for Liver Cancer with Ferrite Materials - A Cooperative Approach from Medical, Physical and Engineering Fields- (in Japanese)

铁氧体材料肝癌高频感应消融疗法的发展——医学、物理和工程领域的合作方法——（日语）

DOI：
发表时间：
2006
期刊：
Bulletin of the Japan Institute for Metals (Materia Japan) 45・9
影响因子：
0
作者：
猶原隆他;猶原隆他;H.Hirazawa et al.;H.Hirazawa et al.;T.Naohara et al.;T.Naohara et al.
通讯作者：
T.Naohara et al.

Preparation of Fine MgCa-Ferrite Powder Having High Heat Generation in an AC Magnetic Field for Thermal Coagulation Therapy

交流磁场中高生热热凝治疗用细镁钙铁氧体粉末的制备