Advancing Methods for MR-guided Focused Ultrasound Hyperthermia for Head and Neck Cancer
推进 MR 引导聚焦超声热疗治疗头颈癌的方法
基本信息
- 批准号:10738459
- 负责人:
- 金额:$ 15.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAcuteAdoptedAftercareAlgorithmsAnatomyAreaAwardBlood flowBrainBreathingCanadaChemotherapy and/or radiationClinicalClinical TrialsComplexDedicationsDeglutitionDevelopmentDoseDrug Delivery SystemsDrug SensitizationEvaluationExcisionFeedbackFocused UltrasoundFocused Ultrasound TherapyGoalsHead and Neck CancerHead and neck structureHealthHeatingHyperthermiaImageImmunotherapyKnowledgeLocationMagnetic Resonance ImagingMalignant NeoplasmsMeasurementMediatingMentorsMetastatic Neoplasm to Lymph NodesMetastatic Neoplasm to the BoneMethodsMonitorMorphologic artifactsMotionMovementNeckOncologyOutcome StudyPancreasPatientsPerfusionPhasePhase I Clinical TrialsPhysiologicalPredispositionProstatePublic HealthRadiationRadiation therapyResearchResearch Project GrantsSafetyShapesSiteSoft tissue sarcomaSonicationSpottingsSquamous cell carcinomaSystemTechniquesTechnologyTemperatureTherapeuticThermal Ablation TherapyThermometryTimeTissuesToxic effectTrainingTransducersUnited StatesUterine Fibroidsblood perfusioncancer therapycancer typechemoradiationchemotherapycostexperienceexperimental studyhigh riskhyperthermia treatmentimage guidedimaging modalityimprovedin silicointerestmagnetic resonance imaging biomarkermelanomanew technologypredictive modelingpreventreconstructionresponsesafety and feasibilitysimulationstandard of caresuccesstranslational scientisttreatment responsetumorultrasound
项目摘要
PROJECT SUMMARY/ABSTRACT
Head and Neck Cancer is a public health concern in the United States and a major challenge in oncology.
Chemoradiotherapy has been mainly adopted to improve survival for patients with head and neck cancers.
However, the benefit remains limited to patients with a high risk of complications, and the burden of toxicity
in surviving patients with head and neck cancers is severe. Hyperthermia combined with other treatments,
such as radiation, chemotherapy, and immunotherapy, has been shown in clinical trials to increase response
for head and neck cancers, but success is highly dependent upon the delivered thermal dose distributions.
Hence, this technology requires spatially controllable heat delivery and adequate temperature monitoring.
MR-guided focused ultrasound (MRgFUS) can potentially be used to deliver hyperthermia. The focused
ultrasound technique has been received much interest due to its completely non-invasive heat delivery with
a high degree of spatial selectivity and dynamic control. With these inherent advantages, clinical MRgFUS
systems have been developed and approved for thermal ablation treatments of various sites, such as the
brain, uterine fibroids, prostate, pancreas, and bone metastases. However, the major technical challenges
remain for MRgFUS hyperthermia delivery to head and neck cancers: There is a need for 1) optimizing
sonication strategies for enhancing temperature distributions and delivering conformal hyperthermia to HNC,
and 2) advanced MR imaging methods for accurate temperature imaging with significantly reduced artifacts
and rapid MR imaging to evaluate tissue response. The proposed project will develop methods for more
effective hyperthermia delivery under magnetic resonance imaging control to increase response rate and
survival for patients with superficial and deep tumors in the head and neck, such as squamous cell carcinoma,
melanoma, and soft tissue sarcoma. In this project, the specific aims are 1) to develop practical and optimal
sonication strategies for conformal delivery of hyperthermia to target head and neck cancer, 2) develop
robust real-time MR thermometry methods for temperature imaging with a minimal artifact in the complex
anatomy of the head and neck, and 3) develop real-time simultaneous MR imaging of temperature and tissue
response during hyperthermia (R00 Phase). These technical developments will advance MRgFUS-mediated
hyperthermia delivery to head and neck cancers and the training plan includes opportunities to apply the
new knowledge. I have assembled an outstanding team of renowned mentors (Drs. Diederich, Larson, and
Payne) and specialized advisors (Drs. Ozhinsky, Bucknor, and Chan) with expertise in MR-guided Focused
Ultrasound therapy, clinical head and neck cancer treatment, quantitative MRI, and MR thermometry. The
proposed award will provide me with the necessary experiences to become an independent, transdisciplinary,
and translational scientist dedicated to image-guided thermal therapy and therapeutic ultrasound.
项目总结/摘要
头颈癌是美国的一个公共卫生问题,也是肿瘤学的一个重大挑战。
放化疗主要用于提高头颈部肿瘤患者的生存率。
然而,受益仍然限于并发症风险高的患者,以及毒性负担
头颈部癌症存活患者的死亡率很高。热疗结合其他治疗,
如放疗、化疗和免疫疗法,已在临床试验中显示可增加反应
但成功与否高度依赖于所输送的热剂量分布。
因此,该技术需要空间可控的热传递和足够的温度监测。
MR引导聚焦超声(MRgFUS)可用于提供热疗。聚焦
超声技术由于其完全非侵入性的热传递而受到广泛关注,
高度的空间选择性和动态控制。凭借这些固有优势,临床MRgFUS
已经开发并批准了用于各种部位的热消融治疗的系统,例如
脑、子宫肌瘤、前列腺、胰腺和骨转移。然而,主要的技术挑战
MRgFUS热疗输送到头颈部癌症:需要1)优化
用于增强温度分布和向HNC递送适形热疗的超声处理策略,
和2)先进的MR成像方法,用于精确的温度成像,显著减少伪影
和快速磁共振成像来评估组织反应。拟议的项目将制定更多的方法,
在磁共振成像控制下有效的热疗递送,以增加响应率,
头颈部浅表和深部肿瘤,如鳞状细胞癌,
黑素瘤和软组织肉瘤。在本项目中,具体目标是:1)开发实用和最佳的
用于适形递送热疗以靶向头颈癌的超声处理策略,2)开发
用于温度成像的鲁棒实时MR测温方法,在复杂环境中具有最小伪影
头部和颈部的解剖结构,以及3)开发温度和组织的实时同步MR成像
热疗期间的反应(R 00阶段)。这些技术发展将推动MRgFUS介导的
热疗输送到头部和颈部癌症和培训计划,包括机会,应用
新知识我组建了一个由著名导师组成的杰出团队(Diederich博士,Larson博士,
Payne)和专业顾问(Ozhinsky博士、Bucknor博士和Chan博士),他们在MR引导的聚焦
超声治疗,临床头颈癌治疗,定量MRI和MR测温。的
建议的奖项将为我提供必要的经验,成为一个独立的,跨学科的,
他是一位致力于图像引导热疗和治疗性超声的翻译科学家。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kisoo Kim其他文献
Kisoo Kim的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
- 批准号:
MR/Y009568/1 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
- 批准号:
10090332 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Collaborative R&D
Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
- 批准号:
MR/X02329X/1 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Fellowship
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
- 批准号:
MR/X021882/1 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
- 批准号:
MR/X029557/1 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Research Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
- 批准号:
EP/Y003527/1 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
- 批准号:
EP/Y030338/1 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
- 批准号:
2312694 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Standard Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
- 批准号:
24K19395 - 财政年份:2024
- 资助金额:
$ 15.49万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Acute human gingivitis systems biology
人类急性牙龈炎系统生物学
- 批准号:
484000 - 财政年份:2023
- 资助金额:
$ 15.49万 - 项目类别:
Operating Grants