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The study of improving effects of nutritional guidance on thrombotic tendency of life style disease

营养指导改善生活方式病血栓倾向的研究

基本信息

批准号：
17500478
负责人：
TAKAYAMA Hiroshi
金额：
$ 2.24万
依托单位：
The University of Shiga Prefecture
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17500478/
关键词：
Nutrition Internal medicine Clinical medicine Hematology Thrombosis and Hemostasis Activated platelets Platelets monocytes complex Membrane rafts 血栓傾向血小板

项目摘要

There were significant positive correlation between BMI, waist circumference, or the total calories of snacks intake and the indicators of thrombotic tendency such as platelet aggregability and the amount of platelet-monocyte complex in the subjects with metabolic syndrome or its pre-state but not in the subjects with diabetes. Those indicators of thrombotic tendency were significantly enhanced in the subjects with diabetes than in the control subjects with pre-diabetes. This suggested that the obesity in the subjects with pre-diabetes was correlated with thrombotic tendency while diabetic pathological state itself further aggravated thrombotic tendency. The amount of platelet-monocyte complex in the blood was significantly and positively correlated with systolic blood pressure but negatively with the amount of food fiber intake in the subjects with diabetes but not in the control subjects with pre-diabets. Therefore, it might be recommended that the subjects with diabetes decrease the … More ir systolic blood pressure to normal level and take more food fiber in order to decrease thrombotic tendency. When we performed the nutritional guidance towards 4 and 2 subjects with and without diabetes, respectively, 3 times over 6 to 8 months, both the indicators of thrombotic tendency and waist circumference were decreased in the subjects without diabetes but not in those with diabetes. The thrombotic tendency observed in the subjects with diabetes might not be able to be improved only by using the nutritional guidance for such a short period.When we gave the food with large amount of cholesterol to rabbits for 3 months, we observed the increases not only in the cholesterol contents in the plasma, platelets, and platelet membrane rafts but also in the platelet GPVI expression levels that positively correlated with platelet aggregability. This suggested that hyper-cholesterolemia resulted in the increased content of cholesterol in platelet membrane rafts leading to enhanced GPVI expression in the rafts and platelet aggregability. Further studies are underway in order to confirm that same phenomena is observed in humans with different levels of plasma cholesterol. Less

在代谢综合征及其前期，BMI、腰围、零食摄入总热量与血小板聚集性、血小板-单核细胞复合物含量等血栓倾向指标呈显著正相关，而在糖尿病患者中无相关性。糖尿病患者血栓形成倾向的指标明显高于糖尿病前期的对照组。提示糖尿病前期患者的肥胖与血栓形成倾向有关，而糖尿病本身的病理状态又进一步加重了血栓形成倾向。血液中血小板-单核细胞复合物的量与收缩压呈显著正相关，但与糖尿病受试者的食物纤维摄入量呈负相关，而在糖尿病前期的对照受试者中则不相关。因此，可能建议糖尿病受试者减少 ...更多信息收缩压降至正常水平，多吃纤维素类食物，以减少血栓形成倾向。当我们分别对4名和2名糖尿病患者和2名非糖尿病患者进行营养指导时，在6至8个月内进行了3次营养指导，非糖尿病患者的血栓形成倾向和腰围指标均下降，但糖尿病患者则没有。在糖尿病受试者中观察到的血栓形成倾向可能仅通过在如此短的时间内使用营养指导无法改善。当我们给兔子大量胆固醇的食物3个月时，我们观察到不仅血浆、血小板中的胆固醇含量增加，而血小板膜筏中GPVI的表达水平也与血小板聚集性呈正相关。这表明高胆固醇血症导致血小板膜筏中胆固醇含量增加，导致筏中GPVI表达增强和血小板聚集性增强。进一步的研究正在进行中，以确认在具有不同血浆胆固醇水平的人类中观察到相同的现象。少