Theoretical Study on Phase Space Landscapes Acquired by Evolution

主要针对生态系统和蛋白质，利用统计和计算物理方法研究了演化组织的相空间景观的特征；对于生态系统，分析了一般的演化动力学模型。在特定的情况下，对于资源的生产力、成熟度和丰度的一些参数，例如生态系统中的物种、细胞中的代谢物、蛋白质和信使核糖核酸的丰度分布被解析地获得。我们还研究了HIV病毒和人类免疫系统的进化动力学，得到了一些参数的无症状项的长度。对于蛋白质，我们研究了马达蛋白的自由能景观，得到了以下结果：(1)我们发现动蛋白和微管蛋白的大结构波动定位在功能重要的区域。特别是，我们的结果表明，由微管蛋白组成的微管对动蛋白起着轨道的作用，它不仅是一个轨道，而且在动蛋白的步进运动中起协同作用(已提交的论文)。(2)研究了肌球蛋白的结构松弛和核苷酸解离的协同性。我们的结果表明，核苷酸的结合和解离改变了自由能格局的结构(提交了一篇论文)。在上述结果的基础上，已有5篇论文发表在国际期刊上，参考文献11。

Mainly for ecosystems and proteins, characteristics of the evolutionarily-organized phase-space landscapes are studied using statistical and computational physics.For ecosystems, general evolutionary dynamics models are analyzed. In special, abundance distributions, e.g. for species in ecosystem, metabolites in cells, proteins and mRNA, is analytically obtained for some parameters of productivity, maturity and abundance of resources. Evolutionary dynamics of HIV virus and human immune system is also studied and the length of the asymptomatic term is obtained for some parameters.For proteins, we studied free-energy landscape of motor proteins and obtained the following results: (1)We found that large structural fluctuations of kinesin and tubulin are localized at functionally important regions. In particular, our results imply that the microtuble, which is composed of tubulin and plays a role of rail for kinesin, is not just a rail but acts cooperatively in stepping motion of kinesin (papers were submitted). (2) We investigate cooperativity of structural relaxation and nucleotide unbinding of myosin. Our results imply that the binding and unbinding of nucleotide switches the the structures of free-energy landscape (a paper was submitted).On the above resuls, five papers have been appeard on international journals listed in 11.REFERENCES.