Immobilization of Photoelectric Dye on the Polyethylene Film Surface -A Prototype Retinal Prosthesis-

光电染料在聚乙烯薄膜表面的固定化-视网膜假体原型-

• 批准号: 17560605
• 负责人: UCHIDA Tetsuya
• 金额: $ 2.3万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17560605/
• 关键词: Photoelectric Dye; Retinal Prosthesis; Polyethylene; Film; Surface

Polyethylene (PE) film was treated with fuming nitric acid at 80°C for 20 min, resulting in introduction of COOH moieties on the film surface. The COOH's were reacted with ethylenediamine, whose amino groups were used for linking with (2-[4-(dibutylamino)phenyl]ethenyl)-3-carboxy-methylbenzo-thiazolium, photoelectric dye (NK-5962), which absorbs visible light and converts the photon energy to electric potentials. The dye molecules were immobilized on the PE film surface and they were able to stimulate chick retinal tissues on incidence of visible light. These facts hopefully lead to development of an artificial retinal prosthesis.

在80°C下用发烟硝酸处理聚乙烯（PE）膜20分钟，导致在膜表面上引入COOH部分。使COOH与乙二胺反应，乙二胺的氨基用于与（2-[4-（二丁基氨基）苯基]乙烯基）-3-羧基-甲基苯并噻唑鎓，光电染料（NK-5962）连接，其吸收可见光并将光子能量转化为电势。将染料分子固定在PE膜表面，在可见光照射下，它们能够刺激鸡视网膜组织。这些事实有望导致人工视网膜假体的发展。

项目成果

The Response and Adhesiveness of Chick Embryonic Retinal Neurons to Photoelectric Dye-Coupled Polyethylene Films as Prototypes of Retinal Prostheses.

鸡胚视网膜神经元对光电染料耦合聚乙烯薄膜作为视网膜假体原型的响应和粘附性。

• 发表时间: 2006
• 期刊: Artificial Organs 30(9)
• 作者: Akihito Uji;Toshihiko Matsuo;Tetsuya Uchida;Kaoru Shimamura;Hiroshi Ohtsuki
• 通讯作者: Hiroshi Ohtsuki

Mixed Neuronal and Glial Colony Formation on the Surface of Photoelectric Dye-Coupled Polyethylene (Okayama University Type Retinal Prosthesis)

光电染料耦合聚乙烯（冈山大学型视网膜假体）表面混合神经元和胶质集落的形成

• 发表时间: 2006
• 期刊: Invest. Ophthalmol. Vis. Sci. 47
• 作者: A.Uji;T.Matsuo;T.Uchida;K.Shimamura;H.Ohtsuki
• 通讯作者: H.Ohtsuki

Photoelectric dye-coupled polyethylene film as a prototype of retinal prostheses

• DOI: 10.1111/j.1525-1594.2004.29010.x
• 发表时间: 2005-01-01
• 期刊: ARTIFICIAL ORGANS
• 影响因子: 2.4
• 作者: Uji, A;Matsuo, T;Suga, S
• 通讯作者: Suga, S

Mixed Neuronal and Glial Colony Formation on the Surface of Photoelectric Dye-Coupled Polyethylene(Okayama University Type Retinal Prosthesis)

光电染料耦合聚乙烯表面混合神经元和胶质集落的形成（冈山大学型视网膜假体）

• 发表时间: 2006
• 期刊: Invest. Ophthalmol. Vis. Sci. 47
• 作者: A.Uji;T.Matsuo;T.Uchida;K.Shimamura;H.Ohtsuki
• 通讯作者: H.Ohtsuki